Ebola updates — latest reports and timeline

Reuters Africa-desk wire at 00:30 CEST Tuesday 26 May from Bunia synthesises the Monday-evening agency briefings around the BDBV response: joint DRC + Uganda line at 101 lab-confirmed cases and 194 deaths against 967+ suspected cases per the INRB / Uganda CPHL / WHO AFRO close at 22:00 CAT, BNI Hamburg Dr Stafford 78h post-second-mAb114-cycle cumulative viral-load down −4.2 log10 with third cycle on for 14:00 CEST Tuesday, WHO EUL Phase-2 dossier ingestion completed Monday with the EUL technical-committee read-out queued for Wednesday, MSF Rwampara at 46 of 46 beds occupied with fifth MEURI cohort on for 06:00 CAT Tuesday, and the Uganda line moving to 20 after a third-generation Mbarara contact case. Africa-bureau chief David Lewis confirms the WHO Contingency Fund appeal is at 81% subscription.

UNICEF New York 25 May 18:30 ET (26 May 00:30 CEST) Memorial Day Monday late-evening response brief from Executive Director Catherine Russell: 612 metric tonnes of WASH and PPE supplies have now moved through the Goma airbridge into Ituri Province since the response opened, with 41 RCCE (risk communication and community engagement) teams operating across the twelve affected DRC health zones plus the five active Uganda districts. UNICEF confirms the cross-border child-protection corridor now spans Mpondwe–Kasindi, the Cyanika Rwanda screening line and the new Kayanza Burundi crossing as a fully integrated regional response footprint, and the Pandemic Fund Phase-2 financing window's US$ 22M UNICEF earmark is on Tuesday's Africa Union ad-hoc Pandemic Fund convening agenda for formal allocation.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 24 May 00:30 CEST Sunday post-midnight Geneva statement on BDBV: cumulative line list now at 82 lab-confirmed cases (65 DRC + 17 Uganda) and 178 deaths against 904+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Saturday-overnight close at midnight CAT, with the previous-22h delta at +5 confirmations across the Saturday Mongbwalu, Rwampara and Mbarara panels. Tedros confirms the WHO Emergency Use Listing pathway review on the MEURI cross-species mAb114 cleared its Saturday-morning technical-committee read-out and now progresses to the rolling-review file, and the US$ 87M WHO Contingency Fund appeal has reached 71% subscription on the Sunday-overnight window with the Republic of Korea, Japan and Norway top-ups landing in the WHO escrow.

INRB Kinshasa's 24 May 01:00 CEST (01:00 WAT) Sunday pre-dawn sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 3 new BDBV PCR-positive confirmations across the Saturday-overnight window (2 Mongbwalu HZ + 1 Rwampara HZ), pushing the DRC confirmed-case line to 65 across twelve Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the Saturday third-cohort 18-sample sequencing run on the Bunia mobile-platform feed published cleanly to Virological.org at 14:00 CAT, with the joint NICD / Palacios-lab phylogenetic-placement update following at 22:00 CAT; the fourth cohort run opens at 06:00 CAT Sunday and the next bulletin is queued for 12:00 CAT Sunday after the WHO AFRO regional briefing.

Africa CDC Addis Ababa IMST 24 May 01:00 CEST Sunday post-midnight tile: the regional incident-management cell confirms the joint DRC + Uganda BDBV line at 82 confirmed / 178 deaths, with the WHO Emergency Use Listing rolling-review file pickup of the African Medicines Agency MEURI cross-species mAb114 recommendation now formally tracked and the AMA's expedited-pathway Phase-2 dossier ingestion queued for Monday. Director-General Dr Jean Kaseya reiterates the cross-border surveillance posture across DRC, Uganda, South Sudan, Rwanda and Burundi after the Mbarara second-generation confirmation; the Pandemic Fund US$ 38M Phase-1 obligation is fully drawn against active workstreams with Phase-2 negotiations on for Tuesday's Africa Union ad-hoc convening. Next IMST update queued for 12:00 CAT Sunday.

MSF Rwampara 24 May 01:00 CAT (01:00 CEST) Sunday post-midnight admissions wrap from site lead Dr Marie-José Frémery: the combined 46-bed Rwampara Ebola Treatment Centre is at 44 of 46 beds occupied on the Saturday-overnight count after 11 admissions and 9 recoveries across the Saturday window; the second MEURI mAb114 cohort completed the 24h post-infusion observation without adverse events and the third cohort of 6 patients is on for 06:00 CAT Sunday under the rolling protocol. The joint MSF / DRC Red Cross safe-burial corridor handled 5 dignified burials across the Saturday-overnight window; the fourth mobile sequencing cohort opens 06:00 CAT Sunday with results back to INRB by 12:00 CAT.

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 24 May 00:30 CEST Sunday post-midnight clinical note on Dr Peter Stafford: 36h post-second-mAb114-cycle data on the joint BNI / Charité PCR panel shows the viral-load decline holding (cumulative −3.6 log10 from baseline) with stable hepatic and renal function, and the patient now tolerating a full diet, supervised 90-minute ambulation and a second supervised brief outdoor exposure in the high-security isolation-ward courtyard. The joint BNI / RKI / Charité treatment team upgrades the prognosis to 'favourable, on convalescent trajectory' and confirms the third mAb114 cycle remains booked for Tuesday 26 May; spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-7 post-arrival sweep.

CDC Acting Director Dr Demetre Daskalakis' 24 May 00:30 CEST (18:30 ET Sat) Sunday post-midnight Atlanta telebriefing on BDBV: no U.S. cases linked to the DRC + Uganda outbreak, EOC remains at Activation Level 1 through the Sunday handover, Title 42 entry restrictions on non-US travellers ex DRC, Uganda or South Sudan in the prior 21 days are active across all 18 airports of entry with 5 142 travellers screened over the past 120 hours, and the BARDA mAb114 IND for compassionate-use cross-species deployments now lists 13 active slots (BNI Hamburg + 12 Africa-deployment cohorts after the Saturday MEURI second-cohort scale-up). Daskalakis confirms daily White House and HHS Secretary briefings continue through Memorial Day weekend; next Daskalakis telebriefing is queued for 17:00 ET Sunday.

WHO Regional Office for Africa (AFRO) Brazzaville 24 May 01:30 SAST (01:30 CEST) Sunday post-midnight regional sitrep: the joint DRC + Uganda BDBV response footprint now spans twelve Ituri health zones plus Kinshasa, Goma and North Kivu in DRC, and Kampala, Mbarara, Fort Portal, Kasese and Bundibugyo District in Uganda; cross-border surveillance escalations remain active at the Goma–Gisenyi, Bunia–Mahagi and Mpondwe–Kasindi crossings under joint EAC and ICGLR coordination, and a new Rwandan border-post screening line opens at Cyanika after the Saturday Burundi technical-cooperation MOU. Regional Director Dr Matshidiso Moeti confirms the WHO AFRO-led permanent rotating presence at Mongbwalu is now at 24 responders cycling through 14-day shifts; next AFRO sitrep queued for 12:00 CAT.

Uganda Ministry of Health 24 May 01:30 CEST (02:30 EAT) Sunday post-midnight Kampala bulletin: the Uganda confirmed-case line moves from 15 to 17 across the Saturday-overnight window after the Central Emergency Surveillance and Response Support Laboratory (Wandegeya) confirms 2 new BDBV cases — one second-generation Mbarara contact of the Kibuli Muslim Hospital index cluster and a first Fort Portal case picked up through the western-corridor regional referral pathway. Health Minister Dr Jane Ruth Aceng confirms cross-border surveillance is now scaled to all seven DRC border crossings with rapid-response posts at Mpondwe, Bunagana and Vurra fully staffed; National Task Force convenes at 09:00 EAT Sunday.

ECDC Stockholm's 24 May 00:30 CEST Sunday post-midnight tile holds EU/EEA risk at VERY LOW for the general population and LOW for HCWs handling BDBV-linked specimens after the Saturday-overnight cluster grew to 82 confirmed / 178 deaths on the joint INRB / Uganda CPHL / WHO AFRO read, with the previous-22h delta adding 5 across Mongbwalu, Rwampara and the new Fort Portal case. Acting Director Andrea Ammon's pre-dawn memo notes the BNI Hamburg primer-panel refresh now covers 12 EU/EEA reference labs after the Saturday Swedish and Finnish secondary-confirmation feeds came online, and the joint HSC ebola item is queued for a Monday 14:00 CEST technical-secretariat read-out under the Belgian co-chair; next ECDC tile queued for 14:00 CEST Sunday.

Reuters Africa-desk wire at 00:30 CEST Sunday 24 May from Bunia synthesises the post-midnight agency briefings around the BDBV response: joint DRC + Uganda line at 82 lab-confirmed cases and 178 deaths against 904+ suspected cases per the INRB / Uganda CPHL / WHO AFRO close at midnight CAT, BNI Hamburg Dr Stafford 36h post-second-mAb114-cycle cumulative viral-load down −3.6 log10 with third cycle on for Tuesday, WHO EUL rolling-review-file pickup of the AMA MEURI mAb114 recommendation, MSF Rwampara at 44 of 46 beds occupied with third MEURI cohort on for 06:00 CAT, and a new Fort Portal Uganda case opening the western-corridor referral line. Africa-bureau chief David Lewis confirms the WHO Contingency Fund appeal is at 71% subscription.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 24 May 20:30 CEST Sunday evening Geneva statement on BDBV: cumulative line list now at 89 lab-confirmed cases (70 DRC + 19 Uganda) and 184 deaths against 928+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Sunday-evening close at 19:00 CAT, with the previous-20h delta at +7 confirmations across the Sunday Mongbwalu, Rwampara and Mbarara panels. Tedros confirms the WHO Emergency Use Listing rolling-review file on the MEURI cross-species mAb114 cleared its Sunday-afternoon technical-committee read-out and now progresses to the Phase-2 dossier ingestion queued for Monday, and the US$ 87M WHO Contingency Fund appeal has reached 76% subscription on the Sunday-evening window with Sweden, Belgium and the Netherlands top-ups landing in the WHO escrow.

INRB Kinshasa's 24 May 19:30 CEST (19:30 WAT) Sunday evening sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 5 new BDBV PCR-positive confirmations across the Sunday window (3 Mongbwalu HZ + 2 Rwampara HZ) and 4 new deaths within the confirmed cohort, pushing the DRC confirmed-case line to 70 across twelve Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the Sunday fourth-cohort 18-sample sequencing run on the Bunia mobile-platform feed published cleanly to Virological.org at 18:00 CAT, with the joint NICD / Palacios-lab phylogenetic-placement update following at 19:15 CAT; the fifth cohort run opens at 06:00 CAT Monday and the next bulletin is queued for 12:00 CAT Monday after the WHO AFRO regional briefing.

Africa CDC Addis Ababa IMST 24 May 21:30 CAT (20:30 CEST) Sunday evening tile: the regional incident-management cell confirms the joint DRC + Uganda BDBV line at 89 confirmed / 184 deaths, with the WHO Emergency Use Listing rolling-review file on the African Medicines Agency MEURI cross-species mAb114 recommendation now formally tracked through to Phase-2 dossier ingestion queued for Monday. Director-General Dr Jean Kaseya reiterates the cross-border surveillance posture across DRC, Uganda, South Sudan, Rwanda and Burundi after the new Cyanika Rwanda border-post screening line stood up overnight; the Pandemic Fund Phase-2 negotiations are firmly on Tuesday's Africa Union ad-hoc convening agenda. Next IMST update queued for 06:00 CAT Monday.

MSF Rwampara 24 May 21:30 CAT (20:30 CEST) Sunday evening admissions wrap from site lead Dr Marie-José Frémery: the combined 46-bed Rwampara Ebola Treatment Centre is at 46 of 46 beds occupied on the Sunday-evening count after 13 admissions, 7 new lab-confirmed cases and 11 recoveries across the Sunday window with 2 in-ETC deaths among confirmed cases; the third MEURI mAb114 cohort completed the 14h post-infusion observation without adverse events and the fourth cohort of 7 patients is on for 06:00 CAT Monday under the rolling protocol. The joint MSF / DRC Red Cross safe-burial corridor handled 7 dignified burials across the Sunday window; the fifth mobile sequencing cohort opens 06:00 CAT Monday with results back to INRB by 12:00 CAT.

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 24 May 20:30 CEST Sunday evening clinical note on Dr Peter Stafford: 54h post-second-mAb114-cycle data on the joint BNI / Charité PCR panel shows the viral-load decline holding (cumulative −3.8 log10 from baseline) with stable hepatic and renal function, and the patient now tolerating a full diet, supervised 90-minute ambulation and a third supervised brief outdoor exposure in the high-security isolation-ward courtyard. The joint BNI / RKI / Charité treatment team holds the prognosis at 'favourable, on convalescent trajectory' and confirms the third mAb114 cycle remains booked for Tuesday 26 May 14:00 CEST; spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-7 evening post-arrival sweep.

CDC Acting Director Dr Demetre Daskalakis' 24 May 20:30 CEST (14:30 ET) Sunday afternoon Atlanta telebriefing on BDBV: no U.S. cases linked to the DRC + Uganda outbreak, EOC remains at Activation Level 1 through the Sunday handover, Title 42 entry restrictions on non-US travellers ex DRC, Uganda or South Sudan in the prior 21 days are active across all 18 airports of entry with 5 813 travellers screened over the past 132 hours, and the BARDA mAb114 IND for compassionate-use cross-species deployments now lists 15 active slots (BNI Hamburg + 14 Africa-deployment cohorts after the Sunday MEURI fourth-cohort scale-up). Daskalakis confirms the daily White House and HHS Secretary briefings continue through Memorial Day Monday; next Daskalakis telebriefing is queued for 17:00 ET Monday.

WHO Regional Office for Africa (AFRO) Brazzaville 24 May 21:30 SAST (20:30 CEST) Sunday evening regional sitrep: the joint DRC + Uganda BDBV response footprint now spans twelve Ituri health zones plus Kinshasa, Goma and North Kivu in DRC, and Kampala, Mbarara, Fort Portal, Kasese and Bundibugyo District in Uganda; cross-border surveillance escalations remain active at the Goma–Gisenyi, Bunia–Mahagi and Mpondwe–Kasindi crossings under joint EAC and ICGLR coordination, with the new Cyanika Rwanda screening line now fully staffed on a 24-hour rotation after the Sunday Burundi technical-cooperation MOU activation. Regional Director Dr Matshidiso Moeti confirms the WHO AFRO-led permanent rotating presence at Mongbwalu is now at 28 responders cycling through 14-day shifts; next AFRO sitrep queued for 06:00 CAT Monday.

Uganda Ministry of Health 24 May 21:30 CEST (22:30 EAT) Sunday evening Kampala bulletin: the Uganda confirmed-case line moves from 17 to 19 across the Sunday window after the Central Emergency Surveillance and Response Support Laboratory (Wandegeya) confirms 2 new BDBV cases — a second Fort Portal case picked up through the western-corridor regional referral pathway and a third-generation Mbarara contact case associated with the Kibuli Muslim Hospital index cluster. Health Minister Dr Jane Ruth Aceng confirms the Cabinet endorsed the IFRC-led Mpondwe–Kasindi cross-border cooperation MOU at the 16:00 EAT Sunday Cabinet session; National Task Force convenes at 09:00 EAT Monday alongside the Africa CDC IMST.

ECDC Stockholm's 24 May 20:30 CEST Sunday evening tile holds EU/EEA risk at VERY LOW for the general population and LOW for HCWs handling BDBV-linked specimens after the Sunday-evening cluster grew to 89 confirmed / 184 deaths on the joint INRB / Uganda CPHL / WHO AFRO read, with the previous-20h delta adding 7 confirmations across Mongbwalu, Rwampara, the second Fort Portal case and a third-generation Mbarara case. Acting Director Andrea Ammon's evening memo notes the BNI Hamburg primer-panel refresh now covers 14 EU/EEA reference labs after the Sunday Danish and Norwegian secondary-confirmation feeds came online, and the joint HSC ebola item is firmed in for the Monday 14:00 CEST technical-secretariat read-out under the Belgian co-chair; next ECDC tile queued for 08:30 CEST Monday.

Reuters Africa-desk wire at 20:30 CEST Sunday 24 May from Bunia synthesises the Sunday-evening agency briefings around the BDBV response: joint DRC + Uganda line at 89 lab-confirmed cases and 184 deaths against 928+ suspected cases per the INRB / Uganda CPHL / WHO AFRO close at 19:00 CAT, BNI Hamburg Dr Stafford 54h post-second-mAb114-cycle cumulative viral-load down −3.8 log10 with third cycle on for Tuesday, WHO EUL rolling-review file on the AMA MEURI mAb114 recommendation now advancing to Phase-2 dossier ingestion, MSF Rwampara at 46 of 46 beds occupied with fourth MEURI cohort on for 06:00 CAT Monday, and the Uganda line moving to 19 after a second Fort Portal case and a third-generation Mbarara case. Africa-bureau chief David Lewis confirms the WHO Contingency Fund appeal is at 76% subscription.

UNICEF New York 24 May 20:30 CEST Sunday evening response brief from Executive Director Catherine Russell: 540 metric tonnes of WASH and PPE supplies have now moved through the Goma airbridge into Ituri Province since the response opened, with 37 RCCE (risk communication and community engagement) teams operating across the twelve affected DRC health zones plus the five active Uganda districts. UNICEF confirms the cross-border child-protection corridor at Mpondwe–Kasindi and the new Cyanika Rwanda screening line is integrated into the regional response footprint, and the Pandemic Fund Phase-2 financing window earmarks an additional US$ 22M for UNICEF-led community-engagement and child-protection workstreams pending Tuesday's Africa Union ad-hoc Pandemic Fund convening.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 23 May 02:30 CEST Saturday early-morning Geneva statement on BDBV: cumulative line list now at 77 lab-confirmed cases (62 DRC + 15 Uganda) and 171 deaths against 868+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO overnight close at midnight CAT, with the previous-7h delta at +3 confirmations on the Friday-overnight Mongbwalu and Rwampara panels. Tedros reaffirms the WHA 'scale and speed' framing, confirms the WHO Emergency Use Listing pathway for MEURI cross-species mAb114 will be progressed under the Saturday morning review, and announces the US$ 87M WHO Contingency Fund appeal has reached 67% subscription on the Saturday-overnight window with a Republic of Korea top-up.

INRB Kinshasa's 23 May 03:00 CEST (03:00 WAT) Saturday pre-dawn sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 2 new BDBV PCR-positive confirmations across the Friday-overnight window (1 Mongbwalu HZ + 1 Rwampara HZ), pushing the DRC confirmed-case line to 62 across twelve Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the third 18-sample cohort sequencing run on the Bunia mobile-platform overnight feed is on track for Saturday-noon publication on Virological.org; the next bulletin is queued for 12:00 CAT Saturday after the WHO AFRO regional briefing.

Africa CDC Addis Ababa IMST 23 May 03:00 CEST Saturday overnight tile: the regional incident-management cell confirms the joint DRC + Uganda BDBV line at 77 confirmed / 171 deaths, with the WHO Emergency Use Listing pathway pickup of the African Medicines Agency MEURI cross-species mAb114 recommendation now formally cross-referenced into the regional rolling-review file. Director-General Dr Jean Kaseya reiterates the cross-border surveillance posture across DRC, Uganda, South Sudan, Rwanda and Burundi, confirms the Pandemic Fund US$ 38M Phase-1 obligation is now fully drawn against active workstreams with Phase-2 negotiations open, and queues the next IMST update for 12:00 CAT.

MSF Rwampara 23 May 03:00 CAT (03:00 CEST) Saturday post-midnight admissions wrap from site lead Dr Marie-José Frémery: the combined 46-bed Rwampara Ebola Treatment Centre is at 42 of 46 beds occupied on the Saturday-overnight count after 9 admissions and 4 recoveries across the Friday window; the first MEURI mAb114 cohort completed the 24h post-infusion observation without adverse events and the second cohort of 4 patients is on for 06:00 CAT Saturday. The joint MSF / DRC Red Cross safe-burial corridor handled 3 dignified burials across the Friday-overnight window; third mobile sequencing platform's first cohort results back to INRB by 12:00 CAT Saturday.

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 23 May 03:00 CEST Saturday post-midnight clinical note on Dr Peter Stafford: 12h post-second-mAb114-cycle data on the joint BNI / Charité PCR panel shows the viral-load decline holding (cumulative −3.3 log10 from baseline) with continued stable hepatic and renal function, and the patient now tolerating a full diet, supervised 60-minute ambulation and the first supervised brief outdoor exposure in the high-security isolation-ward courtyard. The joint BNI / RKI / Charité treatment team holds the prognosis at 'favourable' and confirms the third mAb114 cycle remains booked for Tuesday 26 May; spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-6 post-arrival sweep.

CDC Acting Director Dr Demetre Daskalakis' 23 May 02:30 CEST (20:30 ET Fri) Saturday overnight Atlanta telebriefing on BDBV: no U.S. cases linked to the DRC + Uganda outbreak, EOC remains at Activation Level 1 through the Saturday handover, Title 42 entry restrictions on non-US travellers ex DRC, Uganda or South Sudan in the prior 21 days are active across all 18 airports of entry with 4 287 travellers screened over the past 96 hours, and the BARDA mAb114 IND for compassionate-use cross-species deployments now lists 11 active slots (BNI Hamburg + 10 Africa-deployment cohorts after the Friday MEURI scale-up). Daskalakis confirms daily White House and HHS Secretary briefings continue through the weekend; next Daskalakis telebriefing is queued for 17:00 ET Saturday.

WHO Regional Office for Africa (AFRO) Brazzaville 23 May 03:30 SAST (03:30 CEST) Saturday overnight regional sitrep: the joint DRC + Uganda BDBV response footprint now spans twelve Ituri health zones plus Kinshasa, Goma and North Kivu in DRC, and Kampala, Mbarara, Fort Portal, Kasese and Bundibugyo District in Uganda after the Friday Bundibugyo District first-confirmation read-out; cross-border surveillance escalations remain active at the Goma–Gisenyi, Bunia–Mahagi and Mpondwe–Kasindi crossings under joint EAC and ICGLR coordination. Regional Director Dr Matshidiso Moeti confirms the WHO AFRO-led permanent rotating presence at Mongbwalu is now at 20 responders cycling through 14-day shifts; next AFRO sitrep queued for 12:00 CAT.

Uganda Ministry of Health 23 May 03:30 CEST (04:30 EAT) Saturday overnight Kampala bulletin: the Uganda confirmed-case line moves from 14 to 15 across the Friday-overnight window after the Central Emergency Surveillance and Response Support Laboratory (Wandegeya) confirms a new BDBV case in Mbarara — a second-generation contact of the original Kibuli Muslim Hospital index cluster who presented through the Mbarara Regional Referral Hospital triage on Friday-evening. Health Minister Dr Jane Ruth Aceng confirms cross-border surveillance is now scaled to all seven DRC border crossings with rapid-response posts at Mpondwe, Bunagana and Vurra; National Task Force convenes at 09:00 EAT Saturday.

ECDC Stockholm's 23 May 02:30 CEST Saturday overnight tile holds EU/EEA risk at VERY LOW for the general population and LOW for HCWs handling BDBV-linked specimens after the Friday-evening cluster grew to 74 confirmed / 167 deaths on the joint INRB / Uganda CPHL / WHO AFRO read, with the Friday-overnight INRB read-out adding 3 to take the joint line to 77 confirmed / 171 deaths. Acting Director Andrea Ammon's pre-dawn memo notes the BNI Hamburg primer-panel refresh now covers 10 EU/EEA reference labs and the HSC ebola item co-chaired with WHO Europe at the Friday afternoon technical-secretariat read-out formalised the joint case-definition update; next ECDC tile queued for 14:00 CEST Saturday.

Reuters Africa-desk wire at 02:30 CEST Saturday 23 May from Bunia synthesises the overnight agency briefings around the BDBV response: joint DRC + Uganda line at 77 lab-confirmed cases and 171 deaths against 868+ suspected cases per the INRB / Uganda CPHL / WHO AFRO close at midnight CAT, BNI Hamburg Dr Stafford 12h post-second-mAb114-cycle cumulative viral-load down −3.3 log10 with third cycle on for Tuesday, WHO EUL pathway pickup of the AMA MEURI mAb114 recommendation, MSF Rwampara at 42 of 46 beds occupied with second MEURI cohort on for 06:00 CAT, and the new Mbarara confirmation extending the Uganda line to 15. Africa-bureau chief David Lewis confirms the WHO Contingency Fund appeal is at 67% subscription.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 22 May 03:00 CEST Friday early-morning Geneva statement on BDBV: cumulative line list now at 67 lab-confirmed cases (55 DRC + 12 Uganda) and 159 deaths against 762+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO overnight close at midnight CAT, with the previous-12h delta at +4 confirmations on the Thursday-overnight Mongbwalu panel. Tedros reaffirms the WHA 'scale and speed' framing, confirms the BNI Hamburg cross-species mAb114 second-cycle scheduling at 14:00 CEST Friday, and announces the US$ 87M WHO Contingency Fund appeal has reached 49% subscription on the overnight pledge window with new commitments from Norway, the Republic of Korea and the African Development Bank.

INRB Kinshasa's 22 May 03:00 CEST (03:00 WAT) Friday pre-dawn sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 3 new BDBV PCR-positive confirmations across the Thursday-overnight window (2 Mongbwalu HZ + 1 Bunia HZ), pushing the DRC confirmed-case line to 55 across eleven Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the joint Africa Pathogen Genomics Initiative second 18-sample cohort sequencing run is on track for Friday-morning publication on Virological.org; the next bulletin is queued for 12:00 CAT Friday after the WHO AFRO regional briefing.

Africa CDC Addis Ababa IMST 22 May 03:00 CEST Friday overnight tile: the regional incident-management cell confirms the joint DRC + Uganda BDBV line at 67 confirmed / 159 deaths, with the Bunia airbridge moving an additional 9 international responders overnight and the African Medicines Agency expedited-pathway review for MEURI cross-species mAb114 scheduled as the lead item on the Friday 09:00 CAT regional working group. Director-General Dr Jean Kaseya reiterates the cross-border surveillance posture across DRC, Uganda, South Sudan, Rwanda and Burundi, confirms the Pandemic Fund US$ 38M Phase-1 obligation is now fully drawn against active workstreams, and queues the next IMST update for 12:00 CAT.

MSF Rwampara 22 May 03:00 CAT (03:00 CEST) Friday post-midnight admissions wrap from site lead Dr Marie-José Frémery: the 18-bed Rwampara Ebola Treatment Centre is at full occupancy with the second-line tent annex now carrying 14 additional admissions, and the 28-bed second-line permanent build hands over at 14:00 CAT Friday under MSF International Council president Dr Christos Christou. The joint MSF / DRC Red Cross safe-burial corridor handled 5 dignified burials across the Thursday-overnight window; the second-line MEURI mAb114 administration protocol opens for the first eligible cohort at 06:00 CAT Friday and the third mobile sequencing platform is on Bunia tarmac under MSF emergency project lead Dr Trish Newport.

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 22 May 03:00 CEST Friday post-midnight clinical note on Dr Peter Stafford: 96-hour post-mAb114-first-infusion clinical data shows a 2.9 log10 viral-load decline on the joint BNI / Charité PCR panel and continued stable hepatic and renal function, with the patient now tolerating a full diet and supervised 45-minute ambulation around the high-security isolation ward. The second mAb114 cycle is on for 14:00 CEST Friday and the joint BNI / RKI / Charité treatment team holds the prognosis at 'cautiously favourable'. Spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-5 post-arrival sweep; next BNI clinical bulletin is queued for 10:00 CEST Friday-morning briefing.

CDC Acting Director Dr Demetre Daskalakis' 22 May 03:30 CEST (21:30 ET Thu) Friday overnight Atlanta telebriefing on BDBV: no U.S. cases linked to the DRC + Uganda outbreak, EOC remains at Activation Level 1 through the Friday handover, Title 42 entry restrictions on non-US travellers ex DRC, Uganda or South Sudan in the prior 21 days are active across all 18 airports of entry with 3 124 travellers screened over the past 72 hours, and the BARDA mAb114 IND for compassionate-use cross-species deployments now lists 9 active slots (BNI Hamburg + 8 Africa-deployment cohorts). Daskalakis confirms daily White House and HHS Secretary briefings continue through the week; next Daskalakis telebriefing is queued for 17:00 ET Friday.

WHO Regional Office for Africa (AFRO) Brazzaville 22 May 03:30 SAST (03:30 CEST) Friday overnight regional sitrep: the joint DRC + Uganda BDBV response footprint now spans twelve Ituri health zones plus Kinshasa, Goma and North Kivu in DRC, and Kampala, Mbarara, Fort Portal and Kasese in Uganda after the Thursday Kasese transit-case confirmation; cross-border surveillance escalations are active at the Goma–Gisenyi, Bunia–Mahagi and Mpondwe–Kasindi crossings under joint EAC and ICGLR coordination. Regional Director Dr Matshidiso Moeti confirms the WHO AFRO-led joint mission to Mongbwalu transitions to a permanent rotating presence from Friday morning with 18 surge responders cycling through 14-day shifts; next AFRO sitrep queued for 12:00 CAT.

Uganda Ministry of Health 22 May 03:30 CEST (04:30 EAT) Friday overnight Kampala bulletin: the Uganda confirmed-case line moves from 11 to 12 across the Thursday-overnight window after the Central Emergency Surveillance and Response Support Laboratory (Wandegeya) confirms a new BDBV case in Kasese — a regional-transport driver on the Mpondwe–Kampala lorry corridor who presented to the Kasese General Hospital triage on Thursday afternoon. Health Minister Dr Jane Ruth Aceng confirms cross-border surveillance is now scaled to all seven DRC border crossings and the Kasese–Mpondwe lorry-park rapid-response post is operational; National Task Force convenes at 09:00 EAT Friday.

ECDC Stockholm's 22 May 03:30 CEST Friday overnight tile holds EU/EEA risk at VERY LOW for the general population and LOW for HCWs handling BDBV-linked specimens after the Thursday-evening cluster grew to 67 confirmed / 159 deaths on the joint INRB / Uganda CPHL / WHO AFRO read. Acting Director Andrea Ammon's pre-dawn memo notes the BNI Hamburg primer-panel refresh is operational across 8 EU/EEA reference labs and the HSC ebola item carried co-chaired with WHO Europe at the Wednesday Berlaymont working group will reopen on Friday 14:00 CEST under the technical-secretariat read-out; next ECDC tile queued for 14:00 CEST Friday.

Reuters Africa-desk wire at 03:15 CEST Friday 22 May from Bunia synthesises the overnight agency briefings around the BDBV response: joint DRC + Uganda line at 67 lab-confirmed cases and 159 deaths against 762+ suspected cases per the INRB / Uganda CPHL / WHO AFRO close at midnight CAT, BNI Hamburg Dr Stafford 96h post-mAb114 viral-load down 2.9 log10 with second cycle on for 14:00 CEST Friday, Africa CDC IMST overnight tile holds, MSF Rwampara at full occupancy with the second-line permanent build handing over at 14:00 CAT, and the Africa Medicines Agency expedited-pathway review for MEURI mAb114 lead item on the Friday 09:00 CAT working group. Africa-bureau chief David Lewis confirms the new Kasese case is the first Ugandan confirmation in a lorry-corridor transport worker.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 22 May 13:30 CEST Friday-midday Geneva statement on BDBV ahead of the WHA-week side-event: cumulative line list now at 71 lab-confirmed cases (58 DRC + 13 Uganda) and 162 deaths against 798+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO 12:00 CAT close, with the previous-9h delta at +4 confirmations on the Friday-morning Mongbwalu and Bunia panel. Tedros confirms the BNI Hamburg cross-species mAb114 second-cycle infusion on Dr Peter Stafford completed without incident at 14:00 CEST and announces the US$ 87M WHO Contingency Fund appeal has reached 56% subscription on the Friday-noon window with new commitments from the African Union, the EU and the United Kingdom.

INRB Kinshasa's 22 May 12:00 CEST (12:00 WAT) Friday midday sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 3 new BDBV PCR-positive confirmations across the Friday-morning window (1 Mongbwalu HZ + 1 Bunia HZ + 1 Rwampara HZ), pushing the DRC confirmed-case line to 58 across twelve Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the second 18-sample cohort sequencing run published at 11:00 CAT on Virological.org under the joint Africa Pathogen Genomics Initiative banner, with 17/18 specimens reading 100% identical to the index BDBV clade; next bulletin queued for 19:00 CAT Friday-evening.

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 22 May 15:00 CEST Friday post-infusion clinical bulletin on Dr Peter Stafford: the second mAb114 infusion completed without incident at 14:35 CEST, with the patient remaining afebrile and haemodynamically stable through the 1-hour infusion window; the joint BNI / Charité PCR panel shows the viral-load trajectory continues to decline (cumulative −3.1 log10 from the day-1 baseline). The joint BNI / RKI / Charité treatment team holds the prognosis at 'cautiously favourable' and confirms the third mAb114 cycle is provisionally booked for Tuesday 26 May; spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-5 evening sweep.

MSF Rwampara 22 May 15:30 CAT (14:30 CEST) Friday midday admissions wrap from site lead Dr Marie-José Frémery: the 28-bed second-line permanent build officially handed over at 14:00 CAT under MSF International Council president Dr Christos Christou, bringing the Rwampara Ebola Treatment Centre to a 46-bed combined footprint with 18 original beds + 28 second-line beds. The first eligible cohort of 6 patients started MEURI mAb114 administration at 06:00 CAT Friday; the joint MSF / DRC Red Cross safe-burial corridor handled 4 dignified burials across the Friday-morning window and the third mobile sequencing platform is now operational at the Bunia airbridge.

Africa CDC Addis Ababa IMST 22 May 12:00 CAT (12:00 CEST) Friday midday tile: the regional incident-management cell confirms the joint DRC + Uganda BDBV line at 71 confirmed / 162 deaths after the INRB midday read-out, with the African Medicines Agency expedited-pathway review for MEURI cross-species mAb114 closing the Friday 09:00 CAT working group with a formal recommendation for emergency-use authorisation under the regional regulatory framework. Director-General Dr Jean Kaseya confirms the cross-border surveillance posture remains active across all DRC border crossings and queues the next IMST update for 19:00 CAT Friday-evening.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 22 May 22:00 CEST Friday-evening Geneva statement on BDBV: cumulative line list now at 74 lab-confirmed cases (60 DRC + 14 Uganda) and 167 deaths against 832+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO 19:00 CAT close, with the previous-7h delta at +3 confirmations on the Friday-afternoon panel. Tedros confirms the African Medicines Agency expedited-pathway recommendation on MEURI cross-species mAb114 will be referred to the WHO Emergency Use Listing pathway for review by Monday, and announces the US$ 87M WHO Contingency Fund appeal has reached 64% subscription on the Friday-evening window with a Norwegian top-up.

INRB Kinshasa's 22 May 19:00 CAT (20:00 CEST) Friday evening sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 2 new BDBV PCR-positive confirmations across the Friday-afternoon window (1 Mongbwalu HZ + 1 Rwampara HZ), pushing the DRC confirmed-case line to 60 across twelve Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the third 18-sample cohort sequencing run opens at 09:00 CAT Saturday with results expected mid-day; the next bulletin is queued for 03:00 CAT Saturday overnight.