Novedades de hantavirus — últimos informes y cronología

Reuters Europe-desk wire at 00:30 CEST Tuesday 26 May synthesises the Monday-evening agency briefings around the MV Hondius response: cluster holds at 12 cases / 3 deaths after NICD Sandringham's Monday-morning confirmation of Eindhoven Case 12 moves the case from probable to confirmed (now 11 confirmed + 1 probable), the nine BSL-3 disinfection shifts at the Waalhaven berth complete without exceedances through disinfection day-eight, WHO publishes the post-response evaluation framework ToR with the IHR EC formally stood down, the Bichat ECMO Case 9 patient completed full decannulation at 09:18 CEST Monday on schedule, and the Nebraska NQU cleared the day-17 PCR sweep. Next Reuters update queued for 08:30 CEST Tuesday.

The Dutch Ministry of Health, Welfare and Sport publishes a 26 May 00:30 CEST Tuesday post-midnight note out of The Hague: Minister Daniëlle Jansen confirms the ninth BSL-3 disinfection shift on MV Hondius at the Waalhaven inner-harbour berth wrapped at 19:15 CEST Monday without exceedances on the dockside aerosol-monitoring panels, completing disinfection day-eight on schedule. The 23 single-occupancy crew-quarantine cabins remain at full occupancy on day-15 / day-16, and the tenth shift (galley and food-prep spaces) is on for 09:00 CEST Tuesday; LUMC Leiden and Radboudumc Nijmegen inpatient cohorts remain clinically stable through the late-evening review with no new admissions through the Bank Holiday Monday window.

ECDC Stockholm's 24 May 00:30 CEST Sunday post-midnight tile holds the MV Hondius cluster at 10 lab-confirmed + 1 probable / 3 deaths with zero new cases through the close of the Saturday lab cohort at midnight CEST. Acting Director Andrea Ammon's pre-dawn note marks the case-line as flat for ~168 hours since NICD Sandringham closed Case 8 on 18 May evening, and the HSC passenger-locator pilot day-three read-out again logs zero alert-trigger events across the seven participating EU/EEA member states through the Saturday window. EU/EEA risk held VERY LOW for the general population and LOW for healthcare workers; the next ECDC tile is queued for 14:00 CEST Sunday alongside the Brussels HSC weekend memo.

RIVM's 24 May 00:30 CEST Sunday post-midnight refresh from the Waalhaven dockside: the seventh BSL-3 disinfection shift (galley and food-service cycle) closed at 21:45 CEST Saturday on schedule, and the overnight monitoring window through to the Sunday-morning sweep records no exceedances on the joint Boluda Towage / GGD / Port Health Authority aerosol-monitoring panels — disinfection day-six wraps clean. The 25 dockside-cabin Filipino crew remain on rolling day-15 / day-16 with all asymptomatic and PCR-negative on the overnight courier sweep; LUMC Leiden and Radboudumc Nijmegen inpatient cohorts unchanged. The eighth disinfection shift (bridge and operational spaces) opens 09:00 CEST Sunday after the GGD weekend rotation.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 24 May 00:30 CEST Sunday post-midnight statement on the hantavirus response — the first of the new twice-weekly cadence: the global cluster remains at 11 cases (10 confirmed + 1 probable) / 3 deaths with the case-line flat through the close of the Saturday lab cohort at midnight CEST, the seven completed BSL-3 disinfection shifts on MV Hondius at Waalhaven all wrapped without exceedances, and the cluster has now held flat for ~168 hours since NICD Sandringham confirmed Case 8 on Monday evening. Tedros confirms the post-response evaluation framework terms-of-reference will publish Monday; the IHR Emergency Committee remains formally stood down with the next DG statement queued for Wednesday 27 May.

Santé publique France's 24 May 00:30 CEST Sunday post-midnight point de situation on Bichat Case 9: the partial-decannulation patient remains stable on low-flow venous-only ECMO at the 264h cannulation mark, with lactate held at 1.2 mmol/L on the 00:00 CEST review and right-ventricular function steady on the overnight echo. The joint AP-HP / Bichat / Pitié-Salpêtrière ECMO team confirms full decannulation remains firmly on track for Monday 25 May 09:00 CEST after the final weekend observation window and the patient tolerated supervised bedside chair-transfer on Saturday afternoon; the 26 KL592 / Bichat-cohort contacts remain PCR-negative on the day-13 overnight sweep.

Spain's Ministerio de Sanidad 24 May 00:30 CEST Sunday post-midnight readout: the Gómez Ulla 70-yo Spanish Case 7 patient tolerated a fifth overnight in the ward-step-down general isolation room without supplemental oxygen, afebrile on the 00:00 CEST temperature record, and the joint Sanidad / Comunidad de Madrid case-management group's Sunday 09:00 CEST meeting will firm the discharge protocol with the patient targeted for release at 12:00 CEST Sunday contingent on the day-14 morning PCR sweep returning clear. The 8 Gómez Ulla high-risk close contacts remain PCR-negative on the day-14 overnight sweep; Minister Mónica García's Sunday 11:00 CEST national briefing will close out the inpatient phase.

UKHSA's 24 May 23:30 BST (00:30 CEST) Saturday post-midnight tile: all 22 UK Hondius repatriates from the Tenerife evacuation flight remain asymptomatic on the day-14 overnight PCR sweep with the Arrowe Park Hospital home-isolation cohort closing out the week-two interval cleanly; no UK hantavirus cases and no contact-tracing escalations through the Saturday-to-Sunday overnight cycle. Chief Medical Officer Prof Chris Whitty's pre-dawn note flags the post-week-two step-down review on for Tuesday and confirms UKHSA's host-observer slot on the Monday HSC technical-secretariat lessons-learned working group; next UKHSA tile is queued for 11:00 BST Sunday.

Public Health Agency of Canada 24 May 00:30 CEST (18:30 EDT Sat) Sunday post-midnight Victoria update on Canadian Case 11 (Yukon resident in his 70s): Royal Jubilee Hospital reports the patient holds at fully off supplemental oxygen for a second consecutive overnight, afebrile through the day-14 observation, and the BC Centre for Disease Control day-10 contact-tracing cohort returns PCR-negative across all 11 close contacts on the late-Saturday sweep. PHAC chief PHO Dr Joss Reimer confirms the Sunday 09:00 EDT briefing will formally approve the BC step-down transfer pathway out of acute isolation for mid-next-week; National Microbiology Laboratory Winnipeg 24/7 reference-PCR shift remains active.

NICD Sandringham's 24 May 01:30 SAST (00:30 CEST) Sunday post-midnight lab note: the Tristan da Cunha Case 8 WGS consensus is now formally cross-referenced into the Virological.org / EpiHantavirus joint reference panel, and the joint NICD / Palacios-lab pre-print landed its first peer review-track ingestion at NEJM Catalyst. The Tristan da Cunha companion / spouse cohort remains PCR-negative on the day-19 passive-surveillance sweep and asymptomatic on the day-24 milestone — the islander cohort holds in the post-21-day passive surveillance phase; NICD CEZPD head Prof Jacqueline Weyer queues the next bulletin for 12:00 SAST Sunday and the rotating Cape Town field team continues phased demobilisation.

Nebraska Medicine 24 May 00:30 CEST (17:30 CT Sat) Sunday post-midnight Davis Global Center bulletin: the remaining 14 American MV Hondius repatriates at the UNMC National Quarantine Unit cleared the day-14 PCR sweep across the cohort on the late-Saturday read-out, and the first NQU step-down transfers (10 low-risk asymptomatic contacts) move out of the Davis Global Center isolation suite from 08:00 CT Sunday to onward home-isolation in their states of residence. Acting medical director Dr Angela Hewlett confirms the remaining 4 contacts hold at the NQU pending the day-17 PCR clear; the Davis Global Center isolation suite occupancy drops to 4 from Sunday morning.

Reuters Europe-desk wire at 00:30 CEST Sunday 24 May synthesises the post-midnight agency briefings around the MV Hondius response: cluster holds at 11 cases (10 confirmed + 1 probable) / 3 deaths through the close of the Saturday lab cohort, seven BSL-3 disinfection shifts at the Waalhaven berth complete without exceedances through disinfection day-six, WHO reaffirms global risk LOW under the new twice-weekly DG-statement cadence with the IHR EC formally stood down, ECDC reaffirms EU/EEA risk VERY LOW with the HSC passenger-locator pilot day-three logging zero alert events, the Bichat ECMO Case 9 patient is at 264h on low-flow venous-only support ahead of Monday full decannulation, the Gómez Ulla Spanish Case 7 is on Sunday 12:00 CEST discharge, and the UNMC NQU is releasing 10 of the 14 American repatriates to onward home-isolation. Next Reuters update queued for 13:00 CEST Sunday.

The Dutch Ministry of Health, Welfare and Sport publishes a 24 May 00:30 CEST Sunday post-midnight note out of The Hague: Minister Daniëlle Jansen confirms the seventh BSL-3 disinfection shift on MV Hondius at the Waalhaven inner-harbour berth wrapped at 21:45 CEST Saturday without exceedances on the dockside aerosol-monitoring panels, completing disinfection day-six on schedule. The 23 single-occupancy crew-quarantine cabins remain at full occupancy on day-14 of the 6-week mandatory quarantine, and the eighth shift (bridge and operational spaces) is on for 09:00 CEST Sunday after the GGD weekend rotation. LUMC Leiden and Radboudumc Nijmegen inpatient cohorts remain clinically stable through the night.

Philippine Embassy The Hague and DOH-Manila confirm at 18:00 CEST Sunday 24 May that one of the 38 Filipino MV Hondius crew on preventive quarantine at the Eindhoven cohort housing has been reclassified from asymptomatic-contact to probable case (Case 12) after a day-14 PCR returning a single-reagent positive on the joint RIVM/BNI panel — clinically mild low-grade fever and headache, isolated to the Eindhoven Maxima Medical Centre overnight pending the second-reagent + serology confirmation queued for Monday 25 May 09:00 CEST. The Eindhoven cohort moves from preventive to active monitoring; the new probable pushes the global cluster to 12 cases (10 confirmed + 2 probable) / 3 deaths.

ECDC Stockholm's 24 May 20:30 CEST Sunday evening tile moves the MV Hondius cluster to 12 cases (10 lab-confirmed + 2 probable) / 3 deaths after RIVM's late-afternoon Eindhoven Case 12 reclassification of a Filipino crew member from asymptomatic-contact to probable; the case-line had previously held flat for ~188 hours since NICD Sandringham closed Case 8. Acting Director Andrea Ammon's evening note keeps EU/EEA risk at VERY LOW for the general population and LOW for healthcare workers, logs zero alert-trigger events on the HSC passenger-locator pilot day-three close across the seven participating EU/EEA member states, and queues the next ECDC tile for 08:30 CEST Monday alongside the Brussels HSC technical-secretariat lessons-learned working group.

RIVM's 24 May 20:30 CEST Sunday evening refresh from the Waalhaven dockside: the eighth BSL-3 disinfection shift (bridge and operational spaces) closed at 18:30 CEST on schedule with no exceedances on the joint Boluda Towage / GGD / Port Health Authority aerosol-monitoring panels — disinfection day-seven wraps clean. Separately, RIVM reclassifies a Filipino MV Hondius crew member at the Eindhoven cohort housing from asymptomatic-contact to probable Case 12 after a single-reagent PCR positive on the day-14 sweep; the Eindhoven cohort moves from preventive to active monitoring. The 25 dockside-cabin Filipino crew remain on rolling day-15 / day-16 with all asymptomatic; LUMC Leiden and Radboudumc Nijmegen inpatient cohorts unchanged through the late-evening review.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 24 May 20:30 CEST Sunday evening statement on the hantavirus response — the second of the new twice-weekly cadence: the global cluster moves to 12 cases (10 confirmed + 2 probable) / 3 deaths after the RIVM late-afternoon Eindhoven Case 12 reclassification, the eight completed BSL-3 disinfection shifts on MV Hondius at Waalhaven all wrapped without exceedances, and global risk holds at LOW. Tedros confirms the post-response evaluation framework terms-of-reference publish on Monday 25 May after the IHR Roster sign-off; the IHR Emergency Committee remains formally stood down with the next DG statement queued for Wednesday 27 May 20:30 CEST.

Santé publique France's 24 May 20:30 CEST Sunday evening point de situation on Bichat Case 9: the partial-decannulation patient remains stable on low-flow venous-only ECMO at the 284h cannulation mark, with lactate held at 1.1 mmol/L on the 19:00 CEST review and right-ventricular function steady on the late-afternoon echo. The joint AP-HP / Bichat / Pitié-Salpêtrière ECMO team confirms full decannulation remains firmly on track for Monday 25 May 09:00 CEST after a clean final evening observation window; the patient tolerated a second supervised bedside chair-transfer on Sunday afternoon, and the 26 KL592 / Bichat-cohort contacts remain PCR-negative on the day-14 evening sweep.

Spain's Ministerio de Sanidad 24 May 20:30 CEST Sunday evening readout: the Gómez Ulla 70-yo Spanish Case 7 patient was formally discharged at 12:00 CEST as planned after the morning day-14 PCR sweep returned clear and Minister Mónica García's 11:00 CEST national briefing closed out the inpatient phase. The patient transitions onto a 14-day supervised home-observation protocol with daily symptom logging and a weekly courier-PCR check coordinated through Comunidad de Madrid Salud Pública. The 8 Gómez Ulla high-risk close contacts remain PCR-negative on the day-14 evening sweep; the Gómez Ulla isolation suite stands down to a 24-hour stand-by posture overnight.

UKHSA's 24 May 19:30 BST (20:30 CEST) Sunday evening tile: all 22 UK Hondius repatriates from the Tenerife evacuation flight remain asymptomatic on the day-14 evening PCR sweep with the Arrowe Park Hospital home-isolation cohort cleanly closing out the week-two interval; no UK hantavirus cases and no contact-tracing escalations through the Sunday cycle. Chief Medical Officer Prof Chris Whitty's evening note formally schedules the post-week-two step-down review for Tuesday 26 May 09:00 BST, confirms UKHSA's host-observer slot on the Monday HSC technical-secretariat lessons-learned working group, and queues the next UKHSA tile for 08:00 BST Monday.

Public Health Agency of Canada 24 May 20:30 CEST (14:30 EDT) Sunday evening Victoria update on Canadian Case 11 (Yukon resident in his 70s): Royal Jubilee Hospital reports the patient remains fully off supplemental oxygen through the day-14 evening review, afebrile, and BC Centre for Disease Control's day-10 contact-tracing cohort returns PCR-negative across all 11 close contacts on the late-Sunday sweep. PHAC chief PHO Dr Joss Reimer's evening readout formally approves the BC step-down transfer pathway out of acute isolation for Wednesday 27 May and confirms the National Microbiology Laboratory Winnipeg reference-PCR shift moves from 24/7 to weekday-only from Tuesday.

NICD Sandringham's 24 May 21:30 SAST (20:30 CEST) Sunday evening lab note: the Tristan da Cunha Case 8 WGS consensus is formally accessioned into the NEJM Catalyst peer-review track with the joint NICD / Palacios-lab pre-print at first reviewer dispatch, and the Eindhoven Case 12 single-reagent PCR positive logged by RIVM in the late afternoon is queued onto the NICD Sandringham BSL-3 second-reagent + WGS reference panel for Monday 25 May 07:00 SAST. The Tristan da Cunha companion / spouse cohort remains PCR-negative on the day-19 passive-surveillance sweep and asymptomatic on the day-24 milestone; CEZPD head Prof Jacqueline Weyer queues the next bulletin for 12:00 SAST Monday.

Nebraska Medicine 24 May 20:30 CEST (13:30 CT) Sunday evening Davis Global Center bulletin: the 10 low-risk asymptomatic American MV Hondius contacts cleared from the UNMC National Quarantine Unit at 08:00 CT Sunday were all delivered into onward home-isolation across their respective states of residence by 13:00 CT without incident, and the remaining 4 contacts at the NQU returned PCR-negative on the day-15 evening sweep. Acting medical director Dr Angela Hewlett confirms the remaining cohort holds at the NQU through the day-17 PCR clear scheduled for Tuesday 26 May; the Davis Global Center isolation suite occupancy now stands at 4 from Sunday afternoon.

Reuters Europe-desk wire at 20:30 CEST Sunday 24 May synthesises the Sunday-evening agency briefings around the MV Hondius response: cluster moves to 12 cases (10 confirmed + 2 probable) / 3 deaths after RIVM's late-afternoon Eindhoven Case 12 reclassification of a Filipino crew member, the eight BSL-3 disinfection shifts at the Waalhaven berth complete without exceedances through disinfection day-seven, WHO holds global risk LOW with the new twice-weekly DG-statement cadence and the IHR EC formally stood down, ECDC reaffirms EU/EEA risk VERY LOW with the HSC passenger-locator pilot day-three logging zero alert events, the Bichat ECMO Case 9 patient is at 284h on low-flow venous-only support ahead of Monday full decannulation, and Spain's Gómez Ulla Case 7 was discharged at 12:00 CEST. Next Reuters update queued for 08:30 CEST Monday.

The Dutch Ministry of Health, Welfare and Sport publishes a 24 May 20:30 CEST Sunday evening note out of The Hague: Minister Daniëlle Jansen confirms the eighth BSL-3 disinfection shift on MV Hondius at the Waalhaven inner-harbour berth wrapped at 18:30 CEST without exceedances on the dockside aerosol-monitoring panels, completing disinfection day-seven on schedule. Separately, the Eindhoven cohort housing moves from preventive to active monitoring after a Filipino crew member is reclassified as probable Case 12 by RIVM in the late afternoon. The 23 single-occupancy crew-quarantine cabins remain at full occupancy on day-14, and the ninth shift (laundry and laundromat spaces) is on for 09:00 CEST Monday; LUMC Leiden and Radboudumc Nijmegen inpatient cohorts remain clinically stable through the evening.

ECDC Stockholm's 23 May 02:30 CEST Saturday overnight tile holds the MV Hondius cluster at 10 lab-confirmed + 1 probable / 3 deaths with zero new cases through the close of the Friday lab cohort at midnight CEST. Acting Director Andrea Ammon's pre-dawn memo notes the case-line has now held flat for ~144 hours since NICD-confirmed Case 8 closed out the last lab-pending column on 18 May evening, and the HSC passenger-locator pilot mid-evaluation read-out logs zero alert-trigger events across the seven participating EU/EEA member states through the Friday window. EU/EEA risk held VERY LOW for the general population and LOW for healthcare workers; Saturday 14:00 CEST daily update will pair with the post-pilot extension memo.

RIVM's 23 May 02:30 CEST Saturday overnight refresh from the Waalhaven dockside: the sixth BSL-3 disinfection shift (engine-room cycle) closed at 21:45 CEST Friday on schedule, and the overnight monitoring window through to the Saturday-morning sweep records no exceedances on the joint Boluda Towage / GGD / Port Health Authority aerosol-monitoring panels — disinfection day-five wraps clean. The 25 dockside-cabin Filipino crew remain on rolling day-14 / day-15 with all asymptomatic and PCR-negative on the overnight courier sweep; LUMC Leiden and Radboudumc Nijmegen inpatient cohorts unchanged. The seventh disinfection shift (galley and food-service spaces) opens 09:00 CEST Saturday after the GGD weekend handover.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 23 May 02:00 CEST Saturday early-morning statement on the hantavirus response: the global cluster remains at 11 cases (10 confirmed + 1 probable) / 3 deaths with the case-line flat through the close of the Friday lab cohort at midnight CEST, the six completed BSL-3 disinfection shifts on MV Hondius at Waalhaven all wrapped without exceedances, and the cluster has now held flat for ~144 hours since NICD Sandringham confirmed Case 8 on Monday evening. Tedros confirms the next WHO DG statement will move to the Sunday 24 May twice-weekly cadence; the IHR Emergency Committee remains formally stood down.

Santé publique France's 23 May 02:30 CEST Saturday overnight point de situation on Bichat Case 9: the partial-decannulation patient remains stable on low-flow venous-only ECMO at the 240h cannulation mark, with lactate held at 1.3 mmol/L on the 02:00 CEST review and right-ventricular function steady on the overnight echo. The joint AP-HP / Bichat / Pitié-Salpêtrière ECMO team confirms full decannulation remains on track for Monday 25 May 09:00 CEST after the weekend observation window and the patient continues to tolerate supervised bedside sit-up exercises; the 26 KL592 / Bichat-cohort contacts remain PCR-negative on the day-12 overnight sweep.

Spain's Ministerio de Sanidad 23 May 02:30 CEST Saturday overnight readout: the Gómez Ulla 70-yo Spanish Case 7 patient tolerated a fourth overnight in the ward-step-down general isolation room without supplemental oxygen, afebrile on the 02:00 CEST temperature record, and the joint Sanidad / Comunidad de Madrid case-management group's Saturday 09:00 CEST meeting will firm the Sunday 24 May 12:00 CEST discharge pathway contingent on the day-13 morning PCR sweep returning clear. The 8 Gómez Ulla high-risk close contacts remain PCR-negative on the day-13 overnight sweep; Minister Mónica García's Saturday 11:00 CEST national briefing will close the pre-discharge cycle.

UKHSA's 23 May 01:30 BST (02:30 CEST) Saturday overnight tile: all 22 UK Hondius repatriates from the Tenerife evacuation flight remain asymptomatic on the day-13 overnight PCR sweep with the Arrowe Park Hospital home-isolation cohort now closing out the week-two interval through the weekend; no UK hantavirus cases and no contact-tracing escalations through the Friday-to-Saturday overnight cycle. Chief Medical Officer Prof Chris Whitty's pre-dawn note flags continued joint working with ECDC under the post-HSC framework and confirms UKHSA is the host observer for the Monday HSC technical-secretariat lessons-learned working group; next UKHSA tile is queued for 11:00 BST Saturday.

Public Health Agency of Canada 23 May 02:30 CEST (20:30 EDT Fri) Saturday-overnight Victoria update on Canadian Case 11 (Yukon resident in his 70s): Royal Jubilee Hospital reports the patient fully off supplemental oxygen for the first time since admission, afebrile through the day-13 overnight observation, and the BC Centre for Disease Control day-9 contact-tracing cohort returns PCR-negative across all 11 close contacts on the late-Friday sweep. PHAC chief PHO Dr Joss Reimer confirms the Saturday 09:00 EDT briefing will firm the BC step-down transfer pathway out of acute isolation by mid-next-week; National Microbiology Laboratory Winnipeg 24/7 reference-PCR shift remains active.

NICD Sandringham's 23 May 03:30 SAST (03:30 CEST) Saturday post-midnight lab note: the Tristan da Cunha Case 8 WGS consensus remains fully accessioned on GISAID, EpiHantavirus and Virological.org with the joint NICD / Palacios-lab phylogenetic-placement pre-print now formally posted to Virological.org under the EpiHantavirus reference panel. The Tristan da Cunha companion / spouse cohort remains PCR-negative on the day-18 passive-surveillance sweep and asymptomatic on the day-23 milestone — the islander cohort now formally moves into the post-21-day passive surveillance phase; NICD CEZPD head Prof Jacqueline Weyer queues the next bulletin for 12:00 SAST Saturday and the rotating Cape Town field team begins demobilisation.

Nebraska Medicine 23 May 02:30 CEST (19:30 CT Fri) Saturday post-midnight Davis Global Center bulletin: the remaining 14 American MV Hondius repatriates at the UNMC National Quarantine Unit are asymptomatic on day-13, with the day-13 PCR sweep across the cohort cleared on the late-Friday read-out. Acting medical director Dr Angela Hewlett confirms the cohort is on track for the day-14 milestone over the weekend with the first NQU step-down transfers (low-risk asymptomatic contacts only) now firmly scheduled for Sunday 24 May after the post-day-14 PCR clear; the Davis Global Center isolation suite occupancy holds at 14 for the Saturday-morning sweep.

Reuters Europe-desk wire at 02:30 CEST Saturday 23 May synthesises the overnight agency briefings around the MV Hondius response: cluster holds at 11 cases (10 confirmed + 1 probable) / 3 deaths through the close of the Friday lab cohort, six BSL-3 disinfection shifts at the Waalhaven berth complete without exceedances through disinfection day-five, WHO reaffirms global risk LOW with no PHEIC and IHR EC formally stood down, ECDC reaffirms EU/EEA risk VERY LOW with the HSC passenger-locator pilot mid-evaluation logging zero alert events, the Bichat ECMO Case 9 patient is at 240h on low-flow venous-only support after Friday partial decannulation, and the Gómez Ulla Spanish Case 7 is on Sunday 12:00 CEST discharge. Next Reuters update queued for 13:00 CEST Saturday.

The Dutch Ministry of Health, Welfare and Sport publishes a 23 May 02:30 CEST Saturday overnight note out of The Hague: Minister Daniëlle Jansen confirms the sixth BSL-3 disinfection shift on MV Hondius at the Waalhaven inner-harbour berth wrapped at 21:45 CEST Friday without exceedances on the dockside aerosol-monitoring panels, completing disinfection day-five on schedule. The 23 single-occupancy crew-quarantine cabins remain at full occupancy on day-13 of the 6-week mandatory quarantine, and the seventh shift (galley and food-service spaces) is on for 09:00 CEST Saturday after the GGD weekend handover. LUMC Leiden and Radboudumc Nijmegen inpatient cohorts remain clinically stable through the night.

ECDC Stockholm's 22 May 02:30 CEST Friday overnight tile holds the MV Hondius cluster at 10 lab-confirmed + 1 probable / 3 deaths with zero new cases through the close of the Thursday lab cohort at midnight CEST. Acting Director Andrea Ammon's pre-dawn memo notes the case-line has now held flat for ~108 hours since NICD-confirmed Case 8 closed out the last lab-pending column on 18 May evening, and the post-HSC passenger-management framework's 30-day evaluation pilot enters its second day under ECDC technical secretariat. EU/EEA risk held VERY LOW for the general population and LOW for healthcare workers; Friday 14:00 CEST daily update will pair with the HSC mid-pilot read-out.

RIVM's 22 May 02:30 CEST Friday overnight refresh from the Waalhaven dockside: the fifth BSL-3 disinfection shift (cabin-deck cycle) closed at 21:20 CEST Thursday evening on schedule, and the overnight monitoring window through to the Friday-morning sweep records no exceedances on the joint Boluda Towage / GGD / Port Health Authority aerosol-monitoring panels — disinfection day-four wraps clean. The 25 dockside-cabin Filipino crew remain on rolling day-13 / day-14 with all asymptomatic and PCR-negative on the overnight courier sweep; LUMC Leiden and Radboudumc Nijmegen inpatient cohorts unchanged. The sixth disinfection shift (engine-room cycle) opens 09:00 CEST after the HSC technical-secretariat handover.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 22 May 03:00 CEST Friday early-morning statement on the hantavirus response: the global cluster remains at 11 cases (10 confirmed + 1 probable) / 3 deaths with the case-line flat through the close of the Thursday lab cohort at midnight CEST, all five BSL-3 disinfection shifts on MV Hondius at Waalhaven have wrapped without exceedances, and the cluster has now held flat for ~108 hours since NICD Sandringham confirmed Case 8 on Monday evening. Tedros reaffirms WHO is not considering a PHEIC and the IHR Emergency Committee has been formally stood down; the next WHO DG statement is queued for Sunday 24 May twice-weekly cadence start.

Santé publique France's 22 May 03:00 CEST Friday overnight point de situation on the Bichat ECMO patient (Case 9): the patient remains stable on reduced-flow veno-arterial ECMO at the 216h cannulation mark, lactate held at 1.5 mmol/L on the 02:00 CEST review and right-ventricular function steady on the overnight echo. The joint AP-HP / Bichat / Pitié-Salpêtrière ECMO team confirms partial decannulation is set for 09:00 CEST Friday morning with full decannulation now the working target for the early-next-week window; the 26 KL592 / Bichat-cohort contacts remain PCR-negative on the day-11 overnight sweep.

Spain's Ministerio de Sanidad 22 May 03:15 CEST Friday overnight readout: the Hospital Central de la Defensa Gómez Ulla 70-yo Spanish Hondius patient (Case 7) tolerated the second overnight in the ward-step-down general isolation room without supplemental oxygen, afebrile on the 02:30 CEST temperature record, and the joint Sanidad / Comunidad de Madrid case-management group's Friday 09:00 CEST meeting will firm the Sunday 24 May discharge pathway contingent on the day-12 PCR sweep returning clear. The 8 Gómez Ulla high-risk close contacts remain PCR-negative on the day-11 sweep; Minister Mónica García confirms the Friday 11:00 CEST national press briefing.

UKHSA's 22 May 02:00 BST (03:00 CEST) Friday overnight tile: all 22 UK Hondius repatriates from the Tenerife evacuation flight remain asymptomatic on the day-12 PCR sweep with the Arrowe Park Hospital home-isolation cohort now closing out the second half of the supervised-self-isolation week-two interval; no UK hantavirus cases and no contact-tracing escalations through the Thursday-to-Friday overnight cycle. Chief Medical Officer Prof Chris Whitty's pre-dawn note flags continued joint working with ECDC under the post-HSC framework; the next UKHSA tile is queued for 11:00 BST Friday after the HSC technical-secretariat read-out.

Public Health Agency of Canada 22 May 03:15 CEST (21:15 EDT Thu) Friday-overnight Victoria update on Canadian Case 11 (Yukon resident in his 70s): Royal Jubilee Hospital reports the patient stable on intermittent nasal cannula now mostly off oxygen, afebrile through the day-12 overnight observation; the BC Centre for Disease Control day-8 contact-tracing cohort returns PCR-negative across all 11 close contacts. PHAC chief PHO Dr Joss Reimer confirms the 09:00 EDT Friday briefing cadence, the National Microbiology Laboratory Winnipeg 24/7 reference-PCR shift remains active, and Yukon CMO Dr Catherine Elliott joins the Friday line.

NICD Sandringham's 22 May 03:30 SAST (03:30 CEST) Friday post-midnight lab note: the Tristan da Cunha Case 8 WGS consensus remains fully accessioned on GISAID, EpiHantavirus and Virological.org with the joint NICD / Palacios-lab phylogenetic-placement memo now in the pre-print queue. The Tristan da Cunha companion / spouse cohort remains PCR-negative on the day-17 serial sweep and asymptomatic on the day-22 surveillance milestone — formally closing the 21-day post-exposure observation window for the islander cohort; NICD CEZPD head Prof Jacqueline Weyer queues the next bulletin for 12:00 SAST Friday and the cohort moves to passive surveillance.

Nebraska Medicine 22 May 03:30 CEST (20:30 CT Thu) Friday post-midnight Davis Global Center bulletin: the remaining 14 American MV Hondius repatriates at the UNMC National Quarantine Unit are asymptomatic on day-12, with the day-12 PCR sweep across the cohort cleared on the late-Thursday read-out. Acting medical director Dr Angela Hewlett confirms the cohort is on track for the day-14 milestone over the coming weekend with the first NQU step-down transfers (low-risk asymptomatic contacts only) now scheduled for Sunday 24 May; the Davis Global Center isolation suite occupancy holds at 14 for the Friday-morning sweep.

Reuters Europe-desk wire at 02:30 CEST Friday 22 May synthesises the overnight agency briefings around the MV Hondius response: cluster holds at 11 cases (10 confirmed + 1 probable) / 3 deaths through the close of the Thursday lab cohort, the fifth BSL-3 disinfection shift wrapped on schedule without exceedances at the Waalhaven berth completing disinfection day-four, WHO reaffirms global risk LOW with no PHEIC under consideration and IHR Emergency Committee formally stood down, ECDC reaffirms EU/EEA risk VERY LOW, the Bichat ECMO Case 9 patient is at 216h on reduced-flow support with partial decannulation booked for 09:00 CEST, and the Gómez Ulla Spanish Case 7 completed a second day in general isolation with a Sunday discharge pencilled in. Next Reuters Hondius update is filed for 13:00 CEST Friday.

The Dutch Ministry of Health, Welfare and Sport publishes a 22 May 03:30 CEST Friday overnight note out of The Hague: Minister Daniëlle Jansen confirms the fifth BSL-3 disinfection shift on MV Hondius at the Waalhaven inner-harbour berth wrapped at 21:20 CEST Thursday without exceedances on the dockside aerosol-monitoring panels, completing disinfection day-four on schedule. The 23 single-occupancy crew-quarantine cabins remain at full occupancy on day-12 of the 6-week mandatory quarantine, and the sixth shift (engine-room cycle) is on for 09:00 CEST Friday after the HSC technical-secretariat handover. LUMC Leiden and Radboudumc Nijmegen inpatient cohorts remain clinically stable through the night.

ECDC Stockholm's 22 May 14:00 CEST Friday daily situation update holds the MV Hondius cluster at 10 lab-confirmed + 1 probable / 3 deaths after the Friday morning lab cohort returned no new positives across the joint EU/EEA reference-lab network — case-line now flat for ~132 hours since the NICD Sandringham Case 8 confirmation on Monday evening. The HSC technical-secretariat mid-pilot read-out lands at 13:30 CEST under joint chairs Lahbib and Várhelyi with the passenger-locator pilot running day-2 across seven EU/EEA member states; ECDC formalises 'no further cluster expansion expected' as the operating assumption for the weekend and pushes the next ECDC tile to 22:30 CEST evening.

Santé publique France's 22 May 14:30 CEST Friday midday point de situation: the partial veno-arterial ECMO decannulation on Bichat Case 9 began at 09:15 CEST as scheduled and completed without incident at 11:40 CEST, with the patient now on low-flow venous-only support after 227 hours of cannulation. The joint AP-HP / Bichat / Pitié-Salpêtrière ECMO team reports stable right-ventricular function on the 13:30 CEST post-decannulation echo and lactate at 1.4 mmol/L; the team upgrades the prognosis to 'favourable' and confirms full decannulation is now targeted for Monday 25 May after the weekend observation window. The 26 KL592 / Bichat-cohort contacts day-11 PCR sweep is clear.

Spain's Ministerio de Sanidad 22 May 12:00 CEST Friday-noon La Moncloa briefing led by Minister Mónica García with Health Secretary Padilla: the Gómez Ulla 70-yo Spanish Case 7 patient cleared the day-12 morning PCR sweep with results returned by the Centro Nacional de Microbiología at 11:30 CEST; the joint Sanidad / Comunidad de Madrid case-management group formally pencils the Sunday 24 May 12:00 CEST discharge with a transfer to outpatient follow-up at the Hospital Doce de Octubre infectious-diseases ambulatory clinic. The 8 Gómez Ulla high-risk close contacts remain PCR-negative on the day-12 sweep; the 13 Spanish co-passenger Hondius cohort moves to day-19 of the 42-day active monitoring window.