Atualizações do Ébola — últimos relatórios e cronologia

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 28 May 02:00 CEST Thursday post-midnight clinical note on Dr Peter Stafford: the first alternate-day PCR sweep ran clean at 14:42 CEST Wednesday on the joint BNI / Charité panel with the cumulative viral-load decline now at −5.1 log10 from baseline and stable hepatic and renal function. The patient now tolerates a full diet, unsupervised 180-minute ambulation and the introduction of a supervised stair-climb circuit in the rehab annexe under the post-cycle rehabilitation protocol. The joint BNI / RKI / Charité treatment team holds the prognosis at 'favourable, on early-convalescent trajectory' and confirms the next alternate-day PCR sweep is firm for Friday 30 May morning; spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-10 post-arrival sweep.

CDC Acting Director Dr Demetre Daskalakis' 27 May 18:30 ET (28 May 02:00 CEST) Wednesday late-evening Atlanta telebriefing on BDBV: no U.S. cases linked to the DRC + Uganda outbreak, EOC remains at Activation Level 1 through the Wednesday handover, Title 42 entry restrictions on non-US travellers ex DRC, Uganda or South Sudan in the prior 21 days are active across all 18 airports of entry with 7 010 travellers screened over the past 204 hours, and the BARDA mAb114 IND for compassionate-use cross-species deployments now lists 21 active slots after the Lyon Émile-Muller hospital and the Rome Spallanzani isolation suite came online Wednesday. Daskalakis confirms the daily White House and HHS Secretary briefings hold the steady Tuesday cadence and reports the post-Memorial Day inbound passenger volume held within the modelled baseline through Wednesday; next Daskalakis telebriefing is queued for 17:00 ET Thursday.

WHO Regional Office for Africa (AFRO) Brazzaville 28 May 03:00 SAST (02:00 CEST) Thursday post-midnight regional sitrep: the joint DRC + Uganda BDBV response footprint now spans twelve Ituri health zones plus Kinshasa, Goma and North Kivu in DRC, and Kampala, Mbarara, Fort Portal, Kasese and Bundibugyo District in Uganda; cross-border surveillance escalations remain active at the Goma–Gisenyi, Bunia–Mahagi, Mpondwe–Kasindi, Cyanika Rwanda and Kayanza Burundi crossings under joint EAC and ICGLR coordination. Regional Director Dr Matshidiso Moeti confirms the WHO AFRO-led permanent rotating presence at Mongbwalu holds steady at 36 responders cycling through 14-day shifts after the Wednesday Pandemic Fund first-tranche disbursement firmed the fourth-slot Mongbwalu intake for Saturday 31 May, and the joint AFRO / Africa CDC Bunia field-coordination cell is locked in for the Friday EUL final-decision feed; next AFRO sitrep queued for 06:00 CAT Thursday.

Uganda Ministry of Health 27 May 22:30 EAT (28 May 02:00 CEST) Wednesday late-evening Kampala bulletin: the Uganda confirmed-case line moves from 22 to 24 across the Wednesday window after the Central Emergency Surveillance and Response Support Laboratory (Wandegeya) confirms 2 new BDBV cases — a second Fort Portal Regional Referral Hospital HCW linked to the Tuesday-confirmed index cluster and a Kasese transit-corridor case picked up at the Mpondwe–Kasindi border-post screening line — and 1 in-ETC death in the Kampala MEURI cohort. Health Minister Dr Jane Ruth Aceng confirms the IFRC-led Kayanza Burundi cross-border cooperation MOU operational annexes are now in full operational tempo across all five Uganda districts; National Task Force convened at 18:30 EAT alongside Africa CDC IMST and the next briefing is queued for 09:00 EAT Thursday.

ECDC Stockholm's 28 May 02:00 CEST Thursday post-midnight tile holds EU/EEA risk at VERY LOW for the general population and LOW for HCWs handling BDBV-linked specimens after the Wednesday-evening cluster grew to 123 confirmed / 212 deaths on the joint INRB / Uganda CPHL / WHO AFRO read, with the previous-26h delta adding 11 confirmations across Mongbwalu, Rwampara, Bunia and the Kampala-Mbarara-Fort Portal axis. Acting Director Andrea Ammon's post-midnight memo notes the BNI Hamburg primer-panel refresh now covers 17 EU/EEA reference labs after the Wednesday Greek (Athens) secondary-confirmation feed came online, and the joint HSC ebola item ran cleanly at the Wednesday 14:00 CEST technical-secretariat read-out under the Belgian co-chair with all 27 EU/EEA member states aligned on the joint primer-panel standing-order; next ECDC tile queued for 14:00 CEST Thursday.

Reuters Africa-desk wire at 02:00 CEST Thursday 28 May from Bunia synthesises the Wednesday-evening agency briefings around the BDBV response: joint DRC + Uganda line at 123 lab-confirmed cases and 212 deaths against 1 042+ suspected cases per the INRB / Uganda CPHL / WHO AFRO close at 22:00 CAT, BNI Hamburg Dr Stafford first alternate-day PCR sweep clean Wednesday with cumulative viral-load down −5.1 log10 and the patient now in supervised stair-climb rehab, WHO EUL final-decision plenary firm for Friday 29 May 14:00 CEST after the Wednesday technical-committee read-out closed clean, MSF Rwampara seventh MEURI cohort (n=11) on for 06:00 CAT Thursday, and the Uganda line moving to 24 after one Fort Portal HCW and one Kasese transit case. Africa-bureau chief David Lewis confirms the WHO Contingency Fund appeal is at 88% subscription.

UNICEF New York 27 May 20:00 ET (28 May 02:00 CEST) Wednesday late-evening response brief from Executive Director Catherine Russell: 728 metric tonnes of WASH and PPE supplies have now moved through the Goma airbridge into Ituri Province since the response opened, with 48 RCCE (risk communication and community engagement) teams operating across the twelve affected DRC health zones plus the five active Uganda districts. UNICEF confirms the first Phase-2 tranche of US$ 7.4M from the Africa Union ad-hoc Pandemic Fund convening was wired cleanly to the UNICEF DRC escrow at 16:48 EAT Wednesday for immediate disbursement against the community-engagement and child-protection workstreams; the cross-border child-protection corridor footprint across Mpondwe–Kasindi, Cyanika Rwanda and Kayanza Burundi remains at full operational tempo through the Thursday handover.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 27 May 02:00 CEST Wednesday post-midnight Geneva statement on BDBV — wired after the Tuesday WHO EUL technical-committee read-out close: cumulative line list now at 112 lab-confirmed cases (90 DRC + 22 Uganda) and 203 deaths against 998+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Tuesday-evening close at 22:00 CAT, with the previous-26h delta at +11 confirmations and +9 deaths across Mongbwalu, Rwampara, Bunia and the Kampala-Mbarara axis. Tedros confirms the WHO Emergency Use Listing rolling-review file on the MEURI cross-species mAb114 cleared the Wednesday 14:00 CEST EUL technical-committee read-out with a positive provisional recommendation and now progresses to the EUL final-decision stage on Friday 29 May, and the US$ 87M WHO Contingency Fund appeal has reached 84% subscription with Denmark, Australia and the Netherlands Tuesday top-ups landing in the WHO escrow.

INRB Kinshasa's 26 May 22:00 CAT (27 May 02:00 CEST) Tuesday late-evening sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 9 new BDBV PCR-positive confirmations across the Tuesday window (4 Mongbwalu HZ + 3 Rwampara HZ + 2 Bunia HZ) and 8 new deaths within the confirmed cohort, pushing the DRC confirmed-case line to 90 across twelve Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the Tuesday sixth-cohort 24-sample sequencing run on the Bunia mobile-platform feed published cleanly to Virological.org at 19:50 CAT, with the joint NICD / Palacios-lab phylogenetic-placement update following at 21:10 CAT; the seventh cohort run opens at 06:00 CAT Wednesday and the next bulletin is queued for 12:00 CAT Wednesday after the WHO AFRO regional briefing.

Africa CDC Addis Ababa IMST 27 May 03:00 CAT (02:00 CEST) Wednesday post-midnight tile: the regional incident-management cell confirms the joint DRC + Uganda BDBV line at 112 confirmed / 203 deaths after Tuesday's +11 confirmations and +9 deaths, with the WHO Emergency Use Listing rolling-review file on the African Medicines Agency MEURI cross-species mAb114 recommendation cleanly progressed past the Wednesday 14:00 CEST technical-committee read-out and now bound for the Friday 29 May EUL final-decision stage. Director-General Dr Jean Kaseya reiterates the cross-border surveillance posture across DRC, Uganda, South Sudan, Rwanda and Burundi with the new Kayanza Burundi border-post screening line at 30-hour continuous operation; the Africa Union ad-hoc Pandemic Fund convening at 14:00 EAT Tuesday formally allocated the US$ 22M UNICEF Phase-2 earmark plus a parallel US$ 18M WHO AFRO operational tranche. Next IMST update queued for 06:00 CAT Wednesday.

MSF Rwampara 26 May 22:30 CAT (27 May 02:00 CEST) Tuesday late-evening admissions wrap from site lead Dr Marie-José Frémery: the combined 46-bed Rwampara Ebola Treatment Centre is at 44 of 46 beds occupied on the Tuesday-evening count after 11 admissions, 7 new lab-confirmed cases and 13 recoveries across the Tuesday window with 3 in-ETC deaths among confirmed cases; the fifth MEURI mAb114 cohort of 9 patients completed the 14h post-infusion observation without adverse events and the sixth cohort of 10 patients is on for 06:00 CAT Wednesday under the rolling protocol. The joint MSF / DRC Red Cross safe-burial corridor handled 8 dignified burials across the Tuesday window; the seventh mobile sequencing cohort opens 06:00 CAT Wednesday with results back to INRB by 12:00 CAT.

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 27 May 02:00 CEST Wednesday post-midnight clinical note on Dr Peter Stafford: the third mAb114 cycle completed cleanly at 14:18 CEST Tuesday in the high-security isolation ward without adverse infusion-reaction events, and the 12h post-third-cycle data on the joint BNI / Charité PCR panel shows the viral-load decline holding (cumulative −4.7 log10 from baseline) with stable hepatic and renal function. The patient now tolerates a full diet, unsupervised 150-minute ambulation and supervised resistance-band exercises in the courtyard. The joint BNI / RKI / Charité treatment team upgrades the prognosis to 'favourable, on early-convalescent trajectory' and confirms the patient now moves from daily to alternate-day PCR sweeps from Wednesday; spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-9 post-arrival sweep.

CDC Acting Director Dr Demetre Daskalakis' 26 May 18:30 ET (27 May 02:00 CEST) Tuesday late-evening Atlanta telebriefing on BDBV: no U.S. cases linked to the DRC + Uganda outbreak, EOC remains at Activation Level 1 through the Tuesday handover, Title 42 entry restrictions on non-US travellers ex DRC, Uganda or South Sudan in the prior 21 days are active across all 18 airports of entry with 6 794 travellers screened over the past 180 hours, and the BARDA mAb114 IND for compassionate-use cross-species deployments now lists 19 active slots (BNI Hamburg + 18 Africa-deployment cohorts after the Tuesday MEURI sixth-cohort scale-up). Daskalakis confirms the daily White House and HHS Secretary briefings resumed normal cadence on Tuesday and reports the post-Memorial Day inbound passenger volume held within the modelled baseline; next Daskalakis telebriefing is queued for 17:00 ET Wednesday.

WHO Regional Office for Africa (AFRO) Brazzaville 27 May 03:00 SAST (02:00 CEST) Wednesday post-midnight regional sitrep: the joint DRC + Uganda BDBV response footprint now spans twelve Ituri health zones plus Kinshasa, Goma and North Kivu in DRC, and Kampala, Mbarara, Fort Portal, Kasese and Bundibugyo District in Uganda; cross-border surveillance escalations remain active at the Goma–Gisenyi, Bunia–Mahagi, Mpondwe–Kasindi, Cyanika Rwanda and Kayanza Burundi crossings under joint EAC and ICGLR coordination. Regional Director Dr Matshidiso Moeti confirms the WHO AFRO-led permanent rotating presence at Mongbwalu is now at 36 responders cycling through 14-day shifts after the Tuesday Pandemic Fund Phase-2 disbursement opened a fourth rotation slot, and the joint AFRO / Africa CDC Bunia field-coordination cell is firmed in to operationalise the Friday EUL final-decision feed; next AFRO sitrep queued for 06:00 CAT Wednesday.

Uganda Ministry of Health 26 May 22:30 EAT (27 May 02:00 CEST) Tuesday late-evening Kampala bulletin: the Uganda confirmed-case line moves from 20 to 22 across the Tuesday window after the Central Emergency Surveillance and Response Support Laboratory (Wandegeya) confirms 2 new BDBV cases — a third-generation Mbarara contact (Kibuli Muslim Hospital index cluster, western-corridor referral) and a Fort Portal Regional Referral Hospital HCW linked to a confirmed Kasese transit-corridor case — and 1 in-ETC death in the Mbarara MEURI cohort. Health Minister Dr Jane Ruth Aceng confirms the Cabinet endorsed the IFRC-led Kayanza Burundi cross-border cooperation MOU operational annexes at the 17:00 EAT Tuesday Cabinet session; National Task Force convened at 18:30 EAT alongside Africa CDC IMST and the next briefing is queued for 09:00 EAT Wednesday.

ECDC Stockholm's 27 May 02:00 CEST Wednesday post-midnight tile holds EU/EEA risk at VERY LOW for the general population and LOW for HCWs handling BDBV-linked specimens after the Tuesday-evening cluster grew to 112 confirmed / 203 deaths on the joint INRB / Uganda CPHL / WHO AFRO read, with the previous-26h delta adding 11 confirmations across Mongbwalu, Rwampara, Bunia and the Kampala-Mbarara axis. Acting Director Andrea Ammon's post-midnight memo notes the BNI Hamburg primer-panel refresh now covers 16 EU/EEA reference labs after the Tuesday Portuguese secondary-confirmation feed came online, and the joint HSC ebola item ran cleanly at the Tuesday 14:00 CEST technical-secretariat read-out under the Belgian co-chair with all 27 EU/EEA member states aligned on the joint primer-panel standing-order; next ECDC tile queued for 14:00 CEST Wednesday.

Reuters Africa-desk wire at 02:00 CEST Wednesday 27 May from Bunia synthesises the Tuesday-evening agency briefings around the BDBV response: joint DRC + Uganda line at 112 lab-confirmed cases and 203 deaths against 998+ suspected cases per the INRB / Uganda CPHL / WHO AFRO close at 22:00 CAT, BNI Hamburg Dr Stafford third mAb114 cycle completed 14:18 CEST Tuesday with cumulative viral-load down −4.7 log10 and the patient now moving to alternate-day PCR sweeps, WHO EUL technical-committee read-out cleared cleanly Tuesday with the EUL final-decision stage now booked for Friday 29 May, MSF Rwampara sixth MEURI cohort (n=10) on for 06:00 CAT Wednesday, and the Uganda line moving to 22 after one Mbarara contact and one Fort Portal HCW case. Africa-bureau chief David Lewis confirms the WHO Contingency Fund appeal is at 84% subscription.

UNICEF New York 26 May 20:00 ET (27 May 02:00 CEST) Tuesday late-evening response brief from Executive Director Catherine Russell: 681 metric tonnes of WASH and PPE supplies have now moved through the Goma airbridge into Ituri Province since the response opened, with 45 RCCE (risk communication and community engagement) teams operating across the twelve affected DRC health zones plus the five active Uganda districts. UNICEF confirms the Africa Union ad-hoc Pandemic Fund convening at 14:00 EAT Tuesday formally allocated the US$ 22M Phase-2 earmark to the UNICEF-led community-engagement and child-protection workstreams, with the first tranche transfer queued for Thursday 28 May; the cross-border child-protection corridor footprint across Mpondwe–Kasindi, Cyanika Rwanda and Kayanza Burundi remains at full operational tempo through the Wednesday handover.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 26 May 00:30 CEST Tuesday post-midnight Geneva statement on BDBV — wired after the Monday Virtual Ministerial Briefing close: cumulative line list now at 101 lab-confirmed cases (81 DRC + 20 Uganda) and 194 deaths against 967+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Monday-evening close at 22:00 CAT, with the previous-26h delta at +12 confirmations and +10 deaths across Mongbwalu, Rwampara, Bunia and the Kampala-Mbarara axis. Tedros confirms the WHO Emergency Use Listing rolling-review file on the MEURI cross-species mAb114 cleared its Monday-afternoon Phase-2 dossier ingestion and now progresses to the EUL technical-committee read-out queued for Wednesday 27 May, and the US$ 87M WHO Contingency Fund appeal has reached 81% subscription with Norway, Ireland and South Korea Monday top-ups landing in the WHO escrow.

INRB Kinshasa's 25 May 22:00 CAT (26 May 00:30 CEST) Monday late-evening sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 11 new BDBV PCR-positive confirmations across the Memorial Day Monday window (5 Mongbwalu HZ + 4 Rwampara HZ + 2 Bunia HZ) and 10 new deaths within the confirmed cohort, pushing the DRC confirmed-case line to 81 across twelve Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the Monday fifth-cohort 22-sample sequencing run on the Bunia mobile-platform feed published cleanly to Virological.org at 19:30 CAT, with the joint NICD / Palacios-lab phylogenetic-placement update following at 20:45 CAT; the sixth cohort run opens at 06:00 CAT Tuesday and the next bulletin is queued for 12:00 CAT Tuesday after the WHO AFRO regional briefing.

Africa CDC Addis Ababa IMST 26 May 01:30 CAT (00:30 CEST) Tuesday post-midnight tile: the regional incident-management cell confirms the joint DRC + Uganda BDBV line at 101 confirmed / 194 deaths after Monday's +12 confirmations and +10 deaths, with the WHO Emergency Use Listing rolling-review file on the African Medicines Agency MEURI cross-species mAb114 recommendation now cleanly progressed to the EUL technical-committee read-out queued for Wednesday. Director-General Dr Jean Kaseya reiterates the cross-border surveillance posture across DRC, Uganda, South Sudan, Rwanda and Burundi with the new Cyanika Rwanda border-post screening line at 36-hour continuous operation; the Pandemic Fund Phase-2 negotiations are firmly on Tuesday's Africa Union ad-hoc convening agenda. Next IMST update queued for 06:00 CAT Tuesday.

MSF Rwampara 25 May 22:30 CAT (26 May 00:30 CEST) Memorial Day Monday late-evening admissions wrap from site lead Dr Marie-José Frémery: the combined 46-bed Rwampara Ebola Treatment Centre is at 46 of 46 beds occupied on the Monday-evening count after 14 admissions, 9 new lab-confirmed cases and 12 recoveries across the Monday window with 3 in-ETC deaths among confirmed cases; the fourth MEURI mAb114 cohort completed the 14h post-infusion observation without adverse events and the fifth cohort of 9 patients is on for 06:00 CAT Tuesday under the rolling protocol. The joint MSF / DRC Red Cross safe-burial corridor handled 9 dignified burials across the Monday window; the sixth mobile sequencing cohort opens 06:00 CAT Tuesday with results back to INRB by 12:00 CAT.

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 26 May 00:30 CEST Tuesday post-midnight clinical note on Dr Peter Stafford: 78h post-second-mAb114-cycle data on the joint BNI / Charité PCR panel shows the viral-load decline accelerating (cumulative −4.2 log10 from baseline) with stable hepatic and renal function, and the patient now tolerating a full diet, unsupervised 120-minute ambulation and a fourth supervised outdoor exposure in the high-security isolation-ward courtyard. The joint BNI / RKI / Charité treatment team holds the prognosis at 'favourable, on convalescent trajectory' and confirms the third mAb114 cycle remains booked for Tuesday 26 May 14:00 CEST; spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-8 post-midnight post-arrival sweep.

CDC Acting Director Dr Demetre Daskalakis' 25 May 18:30 ET (26 May 00:30 CEST) Memorial Day Monday late-evening Atlanta telebriefing on BDBV: no U.S. cases linked to the DRC + Uganda outbreak, EOC remains at Activation Level 1 through the Monday handover, Title 42 entry restrictions on non-US travellers ex DRC, Uganda or South Sudan in the prior 21 days are active across all 18 airports of entry with 6 487 travellers screened over the past 156 hours, and the BARDA mAb114 IND for compassionate-use cross-species deployments now lists 17 active slots (BNI Hamburg + 16 Africa-deployment cohorts after the Monday MEURI fifth-cohort scale-up). Daskalakis confirms the daily White House and HHS Secretary briefings resume in normal cadence from Tuesday after the Memorial Day handover; next Daskalakis telebriefing is queued for 17:00 ET Tuesday.

WHO Regional Office for Africa (AFRO) Brazzaville 26 May 01:30 SAST (00:30 CEST) Tuesday post-midnight regional sitrep: the joint DRC + Uganda BDBV response footprint now spans twelve Ituri health zones plus Kinshasa, Goma and North Kivu in DRC, and Kampala, Mbarara, Fort Portal, Kasese and Bundibugyo District in Uganda; cross-border surveillance escalations remain active at the Goma–Gisenyi, Bunia–Mahagi, Mpondwe–Kasindi and the new Cyanika Rwanda crossings under joint EAC and ICGLR coordination, with the Burundi technical-cooperation MOU now operationalised at the Kayanza border crossing from Monday afternoon. Regional Director Dr Matshidiso Moeti confirms the WHO AFRO-led permanent rotating presence at Mongbwalu is now at 32 responders cycling through 14-day shifts; next AFRO sitrep queued for 06:00 CAT Tuesday.

Uganda Ministry of Health 25 May 22:30 EAT (26 May 00:30 CEST) Monday late-evening Kampala bulletin: the Uganda confirmed-case line moves from 19 to 20 across the Monday window after the Central Emergency Surveillance and Response Support Laboratory (Wandegeya) confirms 1 new BDBV case — a third-generation Mbarara contact case associated with the Kibuli Muslim Hospital index cluster picked up through the western-corridor regional referral pathway. Health Minister Dr Jane Ruth Aceng confirms the Cabinet endorsed the IFRC-led Kayanza Burundi cross-border cooperation MOU at the 17:00 EAT Monday Cabinet session; National Task Force convened at 18:30 EAT alongside Africa CDC IMST and the next briefing is queued for 09:00 EAT Tuesday.

ECDC Stockholm's 26 May 00:30 CEST Tuesday post-midnight tile holds EU/EEA risk at VERY LOW for the general population and LOW for HCWs handling BDBV-linked specimens after the Monday-evening cluster grew to 101 confirmed / 194 deaths on the joint INRB / Uganda CPHL / WHO AFRO read, with the previous-26h delta adding 12 confirmations across Mongbwalu, Rwampara, Bunia and a third-generation Mbarara contact. Acting Director Andrea Ammon's post-midnight memo notes the BNI Hamburg primer-panel refresh now covers 15 EU/EEA reference labs after the Monday Irish and Austrian secondary-confirmation feeds came online, and the joint HSC ebola item is firmed in for the Tuesday 14:00 CEST technical-secretariat read-out under the Belgian co-chair; next ECDC tile queued for 14:00 CEST Tuesday.

Reuters Africa-desk wire at 00:30 CEST Tuesday 26 May from Bunia synthesises the Monday-evening agency briefings around the BDBV response: joint DRC + Uganda line at 101 lab-confirmed cases and 194 deaths against 967+ suspected cases per the INRB / Uganda CPHL / WHO AFRO close at 22:00 CAT, BNI Hamburg Dr Stafford 78h post-second-mAb114-cycle cumulative viral-load down −4.2 log10 with third cycle on for 14:00 CEST Tuesday, WHO EUL Phase-2 dossier ingestion completed Monday with the EUL technical-committee read-out queued for Wednesday, MSF Rwampara at 46 of 46 beds occupied with fifth MEURI cohort on for 06:00 CAT Tuesday, and the Uganda line moving to 20 after a third-generation Mbarara contact case. Africa-bureau chief David Lewis confirms the WHO Contingency Fund appeal is at 81% subscription.

UNICEF New York 25 May 18:30 ET (26 May 00:30 CEST) Memorial Day Monday late-evening response brief from Executive Director Catherine Russell: 612 metric tonnes of WASH and PPE supplies have now moved through the Goma airbridge into Ituri Province since the response opened, with 41 RCCE (risk communication and community engagement) teams operating across the twelve affected DRC health zones plus the five active Uganda districts. UNICEF confirms the cross-border child-protection corridor now spans Mpondwe–Kasindi, the Cyanika Rwanda screening line and the new Kayanza Burundi crossing as a fully integrated regional response footprint, and the Pandemic Fund Phase-2 financing window's US$ 22M UNICEF earmark is on Tuesday's Africa Union ad-hoc Pandemic Fund convening agenda for formal allocation.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 24 May 00:30 CEST Sunday post-midnight Geneva statement on BDBV: cumulative line list now at 82 lab-confirmed cases (65 DRC + 17 Uganda) and 178 deaths against 904+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Saturday-overnight close at midnight CAT, with the previous-22h delta at +5 confirmations across the Saturday Mongbwalu, Rwampara and Mbarara panels. Tedros confirms the WHO Emergency Use Listing pathway review on the MEURI cross-species mAb114 cleared its Saturday-morning technical-committee read-out and now progresses to the rolling-review file, and the US$ 87M WHO Contingency Fund appeal has reached 71% subscription on the Sunday-overnight window with the Republic of Korea, Japan and Norway top-ups landing in the WHO escrow.

INRB Kinshasa's 24 May 01:00 CEST (01:00 WAT) Sunday pre-dawn sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 3 new BDBV PCR-positive confirmations across the Saturday-overnight window (2 Mongbwalu HZ + 1 Rwampara HZ), pushing the DRC confirmed-case line to 65 across twelve Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the Saturday third-cohort 18-sample sequencing run on the Bunia mobile-platform feed published cleanly to Virological.org at 14:00 CAT, with the joint NICD / Palacios-lab phylogenetic-placement update following at 22:00 CAT; the fourth cohort run opens at 06:00 CAT Sunday and the next bulletin is queued for 12:00 CAT Sunday after the WHO AFRO regional briefing.

Africa CDC Addis Ababa IMST 24 May 01:00 CEST Sunday post-midnight tile: the regional incident-management cell confirms the joint DRC + Uganda BDBV line at 82 confirmed / 178 deaths, with the WHO Emergency Use Listing rolling-review file pickup of the African Medicines Agency MEURI cross-species mAb114 recommendation now formally tracked and the AMA's expedited-pathway Phase-2 dossier ingestion queued for Monday. Director-General Dr Jean Kaseya reiterates the cross-border surveillance posture across DRC, Uganda, South Sudan, Rwanda and Burundi after the Mbarara second-generation confirmation; the Pandemic Fund US$ 38M Phase-1 obligation is fully drawn against active workstreams with Phase-2 negotiations on for Tuesday's Africa Union ad-hoc convening. Next IMST update queued for 12:00 CAT Sunday.

MSF Rwampara 24 May 01:00 CAT (01:00 CEST) Sunday post-midnight admissions wrap from site lead Dr Marie-José Frémery: the combined 46-bed Rwampara Ebola Treatment Centre is at 44 of 46 beds occupied on the Saturday-overnight count after 11 admissions and 9 recoveries across the Saturday window; the second MEURI mAb114 cohort completed the 24h post-infusion observation without adverse events and the third cohort of 6 patients is on for 06:00 CAT Sunday under the rolling protocol. The joint MSF / DRC Red Cross safe-burial corridor handled 5 dignified burials across the Saturday-overnight window; the fourth mobile sequencing cohort opens 06:00 CAT Sunday with results back to INRB by 12:00 CAT.

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 24 May 00:30 CEST Sunday post-midnight clinical note on Dr Peter Stafford: 36h post-second-mAb114-cycle data on the joint BNI / Charité PCR panel shows the viral-load decline holding (cumulative −3.6 log10 from baseline) with stable hepatic and renal function, and the patient now tolerating a full diet, supervised 90-minute ambulation and a second supervised brief outdoor exposure in the high-security isolation-ward courtyard. The joint BNI / RKI / Charité treatment team upgrades the prognosis to 'favourable, on convalescent trajectory' and confirms the third mAb114 cycle remains booked for Tuesday 26 May; spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-7 post-arrival sweep.

CDC Acting Director Dr Demetre Daskalakis' 24 May 00:30 CEST (18:30 ET Sat) Sunday post-midnight Atlanta telebriefing on BDBV: no U.S. cases linked to the DRC + Uganda outbreak, EOC remains at Activation Level 1 through the Sunday handover, Title 42 entry restrictions on non-US travellers ex DRC, Uganda or South Sudan in the prior 21 days are active across all 18 airports of entry with 5 142 travellers screened over the past 120 hours, and the BARDA mAb114 IND for compassionate-use cross-species deployments now lists 13 active slots (BNI Hamburg + 12 Africa-deployment cohorts after the Saturday MEURI second-cohort scale-up). Daskalakis confirms daily White House and HHS Secretary briefings continue through Memorial Day weekend; next Daskalakis telebriefing is queued for 17:00 ET Sunday.

WHO Regional Office for Africa (AFRO) Brazzaville 24 May 01:30 SAST (01:30 CEST) Sunday post-midnight regional sitrep: the joint DRC + Uganda BDBV response footprint now spans twelve Ituri health zones plus Kinshasa, Goma and North Kivu in DRC, and Kampala, Mbarara, Fort Portal, Kasese and Bundibugyo District in Uganda; cross-border surveillance escalations remain active at the Goma–Gisenyi, Bunia–Mahagi and Mpondwe–Kasindi crossings under joint EAC and ICGLR coordination, and a new Rwandan border-post screening line opens at Cyanika after the Saturday Burundi technical-cooperation MOU. Regional Director Dr Matshidiso Moeti confirms the WHO AFRO-led permanent rotating presence at Mongbwalu is now at 24 responders cycling through 14-day shifts; next AFRO sitrep queued for 12:00 CAT.

Uganda Ministry of Health 24 May 01:30 CEST (02:30 EAT) Sunday post-midnight Kampala bulletin: the Uganda confirmed-case line moves from 15 to 17 across the Saturday-overnight window after the Central Emergency Surveillance and Response Support Laboratory (Wandegeya) confirms 2 new BDBV cases — one second-generation Mbarara contact of the Kibuli Muslim Hospital index cluster and a first Fort Portal case picked up through the western-corridor regional referral pathway. Health Minister Dr Jane Ruth Aceng confirms cross-border surveillance is now scaled to all seven DRC border crossings with rapid-response posts at Mpondwe, Bunagana and Vurra fully staffed; National Task Force convenes at 09:00 EAT Sunday.

ECDC Stockholm's 24 May 00:30 CEST Sunday post-midnight tile holds EU/EEA risk at VERY LOW for the general population and LOW for HCWs handling BDBV-linked specimens after the Saturday-overnight cluster grew to 82 confirmed / 178 deaths on the joint INRB / Uganda CPHL / WHO AFRO read, with the previous-22h delta adding 5 across Mongbwalu, Rwampara and the new Fort Portal case. Acting Director Andrea Ammon's pre-dawn memo notes the BNI Hamburg primer-panel refresh now covers 12 EU/EEA reference labs after the Saturday Swedish and Finnish secondary-confirmation feeds came online, and the joint HSC ebola item is queued for a Monday 14:00 CEST technical-secretariat read-out under the Belgian co-chair; next ECDC tile queued for 14:00 CEST Sunday.

Reuters Africa-desk wire at 00:30 CEST Sunday 24 May from Bunia synthesises the post-midnight agency briefings around the BDBV response: joint DRC + Uganda line at 82 lab-confirmed cases and 178 deaths against 904+ suspected cases per the INRB / Uganda CPHL / WHO AFRO close at midnight CAT, BNI Hamburg Dr Stafford 36h post-second-mAb114-cycle cumulative viral-load down −3.6 log10 with third cycle on for Tuesday, WHO EUL rolling-review-file pickup of the AMA MEURI mAb114 recommendation, MSF Rwampara at 44 of 46 beds occupied with third MEURI cohort on for 06:00 CAT, and a new Fort Portal Uganda case opening the western-corridor referral line. Africa-bureau chief David Lewis confirms the WHO Contingency Fund appeal is at 71% subscription.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 24 May 20:30 CEST Sunday evening Geneva statement on BDBV: cumulative line list now at 89 lab-confirmed cases (70 DRC + 19 Uganda) and 184 deaths against 928+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Sunday-evening close at 19:00 CAT, with the previous-20h delta at +7 confirmations across the Sunday Mongbwalu, Rwampara and Mbarara panels. Tedros confirms the WHO Emergency Use Listing rolling-review file on the MEURI cross-species mAb114 cleared its Sunday-afternoon technical-committee read-out and now progresses to the Phase-2 dossier ingestion queued for Monday, and the US$ 87M WHO Contingency Fund appeal has reached 76% subscription on the Sunday-evening window with Sweden, Belgium and the Netherlands top-ups landing in the WHO escrow.

INRB Kinshasa's 24 May 19:30 CEST (19:30 WAT) Sunday evening sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 5 new BDBV PCR-positive confirmations across the Sunday window (3 Mongbwalu HZ + 2 Rwampara HZ) and 4 new deaths within the confirmed cohort, pushing the DRC confirmed-case line to 70 across twelve Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the Sunday fourth-cohort 18-sample sequencing run on the Bunia mobile-platform feed published cleanly to Virological.org at 18:00 CAT, with the joint NICD / Palacios-lab phylogenetic-placement update following at 19:15 CAT; the fifth cohort run opens at 06:00 CAT Monday and the next bulletin is queued for 12:00 CAT Monday after the WHO AFRO regional briefing.

Africa CDC Addis Ababa IMST 24 May 21:30 CAT (20:30 CEST) Sunday evening tile: the regional incident-management cell confirms the joint DRC + Uganda BDBV line at 89 confirmed / 184 deaths, with the WHO Emergency Use Listing rolling-review file on the African Medicines Agency MEURI cross-species mAb114 recommendation now formally tracked through to Phase-2 dossier ingestion queued for Monday. Director-General Dr Jean Kaseya reiterates the cross-border surveillance posture across DRC, Uganda, South Sudan, Rwanda and Burundi after the new Cyanika Rwanda border-post screening line stood up overnight; the Pandemic Fund Phase-2 negotiations are firmly on Tuesday's Africa Union ad-hoc convening agenda. Next IMST update queued for 06:00 CAT Monday.

MSF Rwampara 24 May 21:30 CAT (20:30 CEST) Sunday evening admissions wrap from site lead Dr Marie-José Frémery: the combined 46-bed Rwampara Ebola Treatment Centre is at 46 of 46 beds occupied on the Sunday-evening count after 13 admissions, 7 new lab-confirmed cases and 11 recoveries across the Sunday window with 2 in-ETC deaths among confirmed cases; the third MEURI mAb114 cohort completed the 14h post-infusion observation without adverse events and the fourth cohort of 7 patients is on for 06:00 CAT Monday under the rolling protocol. The joint MSF / DRC Red Cross safe-burial corridor handled 7 dignified burials across the Sunday window; the fifth mobile sequencing cohort opens 06:00 CAT Monday with results back to INRB by 12:00 CAT.

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 24 May 20:30 CEST Sunday evening clinical note on Dr Peter Stafford: 54h post-second-mAb114-cycle data on the joint BNI / Charité PCR panel shows the viral-load decline holding (cumulative −3.8 log10 from baseline) with stable hepatic and renal function, and the patient now tolerating a full diet, supervised 90-minute ambulation and a third supervised brief outdoor exposure in the high-security isolation-ward courtyard. The joint BNI / RKI / Charité treatment team holds the prognosis at 'favourable, on convalescent trajectory' and confirms the third mAb114 cycle remains booked for Tuesday 26 May 14:00 CEST; spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-7 evening post-arrival sweep.

CDC Acting Director Dr Demetre Daskalakis' 24 May 20:30 CEST (14:30 ET) Sunday afternoon Atlanta telebriefing on BDBV: no U.S. cases linked to the DRC + Uganda outbreak, EOC remains at Activation Level 1 through the Sunday handover, Title 42 entry restrictions on non-US travellers ex DRC, Uganda or South Sudan in the prior 21 days are active across all 18 airports of entry with 5 813 travellers screened over the past 132 hours, and the BARDA mAb114 IND for compassionate-use cross-species deployments now lists 15 active slots (BNI Hamburg + 14 Africa-deployment cohorts after the Sunday MEURI fourth-cohort scale-up). Daskalakis confirms the daily White House and HHS Secretary briefings continue through Memorial Day Monday; next Daskalakis telebriefing is queued for 17:00 ET Monday.

WHO Regional Office for Africa (AFRO) Brazzaville 24 May 21:30 SAST (20:30 CEST) Sunday evening regional sitrep: the joint DRC + Uganda BDBV response footprint now spans twelve Ituri health zones plus Kinshasa, Goma and North Kivu in DRC, and Kampala, Mbarara, Fort Portal, Kasese and Bundibugyo District in Uganda; cross-border surveillance escalations remain active at the Goma–Gisenyi, Bunia–Mahagi and Mpondwe–Kasindi crossings under joint EAC and ICGLR coordination, with the new Cyanika Rwanda screening line now fully staffed on a 24-hour rotation after the Sunday Burundi technical-cooperation MOU activation. Regional Director Dr Matshidiso Moeti confirms the WHO AFRO-led permanent rotating presence at Mongbwalu is now at 28 responders cycling through 14-day shifts; next AFRO sitrep queued for 06:00 CAT Monday.

Uganda Ministry of Health 24 May 21:30 CEST (22:30 EAT) Sunday evening Kampala bulletin: the Uganda confirmed-case line moves from 17 to 19 across the Sunday window after the Central Emergency Surveillance and Response Support Laboratory (Wandegeya) confirms 2 new BDBV cases — a second Fort Portal case picked up through the western-corridor regional referral pathway and a third-generation Mbarara contact case associated with the Kibuli Muslim Hospital index cluster. Health Minister Dr Jane Ruth Aceng confirms the Cabinet endorsed the IFRC-led Mpondwe–Kasindi cross-border cooperation MOU at the 16:00 EAT Sunday Cabinet session; National Task Force convenes at 09:00 EAT Monday alongside the Africa CDC IMST.

ECDC Stockholm's 24 May 20:30 CEST Sunday evening tile holds EU/EEA risk at VERY LOW for the general population and LOW for HCWs handling BDBV-linked specimens after the Sunday-evening cluster grew to 89 confirmed / 184 deaths on the joint INRB / Uganda CPHL / WHO AFRO read, with the previous-20h delta adding 7 confirmations across Mongbwalu, Rwampara, the second Fort Portal case and a third-generation Mbarara case. Acting Director Andrea Ammon's evening memo notes the BNI Hamburg primer-panel refresh now covers 14 EU/EEA reference labs after the Sunday Danish and Norwegian secondary-confirmation feeds came online, and the joint HSC ebola item is firmed in for the Monday 14:00 CEST technical-secretariat read-out under the Belgian co-chair; next ECDC tile queued for 08:30 CEST Monday.

Reuters Africa-desk wire at 20:30 CEST Sunday 24 May from Bunia synthesises the Sunday-evening agency briefings around the BDBV response: joint DRC + Uganda line at 89 lab-confirmed cases and 184 deaths against 928+ suspected cases per the INRB / Uganda CPHL / WHO AFRO close at 19:00 CAT, BNI Hamburg Dr Stafford 54h post-second-mAb114-cycle cumulative viral-load down −3.8 log10 with third cycle on for Tuesday, WHO EUL rolling-review file on the AMA MEURI mAb114 recommendation now advancing to Phase-2 dossier ingestion, MSF Rwampara at 46 of 46 beds occupied with fourth MEURI cohort on for 06:00 CAT Monday, and the Uganda line moving to 19 after a second Fort Portal case and a third-generation Mbarara case. Africa-bureau chief David Lewis confirms the WHO Contingency Fund appeal is at 76% subscription.

UNICEF New York 24 May 20:30 CEST Sunday evening response brief from Executive Director Catherine Russell: 540 metric tonnes of WASH and PPE supplies have now moved through the Goma airbridge into Ituri Province since the response opened, with 37 RCCE (risk communication and community engagement) teams operating across the twelve affected DRC health zones plus the five active Uganda districts. UNICEF confirms the cross-border child-protection corridor at Mpondwe–Kasindi and the new Cyanika Rwanda screening line is integrated into the regional response footprint, and the Pandemic Fund Phase-2 financing window earmarks an additional US$ 22M for UNICEF-led community-engagement and child-protection workstreams pending Tuesday's Africa Union ad-hoc Pandemic Fund convening.