Novedades del Ébola — últimos informes y cronología

Uganda Ministry of Health 6 June 22:30 EAT (7 June 02:00 CEST) Saturday late-evening Kampala bulletin: the Uganda confirmed line moves from 37 to 38 after a single new BDBV confirmation in a known Mbarara cluster contact, with no new deaths across the Saturday window — a sixth consecutive zero-death day. Health Minister Dr Jane Ruth Aceng confirms all 38 Uganda cases remain linked to identified clusters with no community-source transmission detected, and the Mulago and Mbarara MEURI mAb114 cohorts continue without adverse events; the Mpondwe–Kasindi, Bunagana and Kasese border-screening lines hold at continuous operation and the next briefing is queued for 09:00 EAT Sunday.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 6 June 03:00 CEST Saturday post-midnight Geneva statement on BDBV: cumulative line list at 257 lab-confirmed cases (220 DRC + 37 Uganda) and 253 deaths against 1 400+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Friday-evening close, with the previous-24h confirmed-case and death deltas both holding at their lowest since the outbreak was declared. Tedros reports the original Mongbwalu focus logged another zero-new-confirmation day on Friday and the Rwampara curve continues to fall, while residual transmission concentrates on the Bunia and Kampala–Mbarara axes; the provisional 21-day zero-incidence countdown clock for the Mongbwalu health zone is now on its fourth day. WHO holds the PHEIC in force on the twice-weekly (Wednesday and Saturday) DG-statement cadence as the response consolidates into sustained control; next DG statement queued for Wednesday 10 June.

INRB Kinshasa's 5 June 22:00 CAT (6 June 02:00 CEST) Friday late-evening tally: 6 new BDBV PCR-positive confirmations across the Friday window (0 Mongbwalu + 3 Rwampara + 3 Bunia) and 1 new death within the confirmed cohort, taking the DRC confirmed line to 220 — a fresh low for the single-window confirmation count since the outbreak was declared. The Mongbwalu index focus held to zero confirmations across the Friday window, with the provisional 21-day zero-incidence countdown clock for the health zone now on its fourth day; Rwampara and Bunia remain the residual foci. Director Prof Jean-Jacques Muyembe-Tamfum confirms the sixteenth-cohort sequencing run posted cleanly to Virological.org under the post-EUL data-share protocol — phylogenetic placement still shows a single BDBV introduction with no second spillover — and the seventeenth cohort opens 06:00 CAT Saturday.

MSF Rwampara 5 June 22:30 CAT (6 June 02:00 CEST) Friday late-evening admissions wrap: 3 new lab-confirmed cases, 13 recoveries and no in-ETC deaths across the Friday window — recoveries outpaced admissions for a seventh consecutive day, combined Rwampara + Bunia-annexe occupancy eased to 18 of 58 beds, and the network logged its second consecutive full day without an in-centre death. Site lead Dr Marie-José Frémery reports the fifteenth MEURI mAb114 cohort completed 14h post-infusion observation without adverse events and the cumulative confirmed-case fatality ratio inside the ETC network now sits below 17% for patients admitted within 48h of symptom onset and below 9% for those admitted within 24h; the joint MSF / DRC Red Cross safe-and-dignified-burial corridor handled 1 dignified burial.

Uganda Ministry of Health 5 June 22:30 EAT (6 June 02:00 CEST) Friday late-evening Kampala bulletin: the Uganda confirmed line moves from 36 to 37 after a single new BDBV confirmation in a known Mbarara cluster contact, with no new deaths across the Friday window — a fifth consecutive zero-death day. Health Minister Dr Jane Ruth Aceng confirms all 37 Uganda cases remain linked to identified clusters with no community-source transmission detected, and the Mulago and Mbarara MEURI mAb114 cohorts continue without adverse events; the Mpondwe–Kasindi, Bunagana and Kasese border-screening lines hold at continuous operation and the next briefing is queued for 09:00 EAT Saturday.

INRB Kinshasa's 4 June 22:00 CAT (5 June 02:00 CEST) Thursday late-evening tally: 7 new BDBV PCR-positive confirmations across the Thursday window (1 Mongbwalu + 3 Rwampara + 3 Bunia) and 1 new death within the confirmed cohort, taking the DRC confirmed line to 214 — the lowest single-window confirmation count since the outbreak was declared. The Mongbwalu index focus held to a single confirmation, with the provisional 21-day zero-incidence countdown clock for the health zone now on its third day; Rwampara and Bunia remain the residual foci. Director Prof Jean-Jacques Muyembe-Tamfum confirms the fifteenth-cohort sequencing run posted cleanly to Virological.org under the post-EUL data-share protocol — phylogenetic placement still shows a single BDBV introduction with no second spillover — and the sixteenth cohort opens 06:00 CAT Friday.

MSF Rwampara 4 June 22:30 CAT (5 June 02:00 CEST) Thursday late-evening admissions wrap: 4 new lab-confirmed cases, 15 recoveries and no in-ETC deaths across the Thursday window — recoveries outpaced admissions for a sixth consecutive day, combined Rwampara + Bunia-annexe occupancy eased to 22 of 58 beds, and the network logged its first full day without an in-centre death since the ETC opened. Site lead Dr Marie-José Frémery reports the fourteenth MEURI mAb114 cohort completed 14h post-infusion observation without adverse events and the cumulative confirmed-case fatality ratio inside the ETC network now sits below 18% for patients admitted within 48h of symptom onset and below 10% for those admitted within 24h; the joint MSF / DRC Red Cross safe-and-dignified-burial corridor handled 1 dignified burial.

Uganda Ministry of Health 4 June 22:30 EAT (5 June 02:00 CEST) Thursday late-evening Kampala bulletin: the Uganda confirmed line moves from 35 to 36 after a single new BDBV confirmation in a known Mbarara cluster contact, with no new deaths across the Thursday window — a fourth consecutive zero-death day. Health Minister Dr Jane Ruth Aceng confirms all 36 Uganda cases remain linked to identified clusters with no community-source transmission detected, and the Mulago and Mbarara MEURI mAb114 cohorts continue without adverse events; the Mpondwe–Kasindi, Bunagana and Kasese border-screening lines hold at continuous operation and the next briefing is queued for 09:00 EAT Friday.

INRB Kinshasa's 3 June 22:00 CAT (4 June 02:00 CEST) Wednesday late-evening tally: 9 new BDBV PCR-positive confirmations across the Wednesday window (2 Mongbwalu + 4 Rwampara + 3 Bunia) and 2 new deaths within the confirmed cohort, taking the DRC confirmed line to 207. The Mongbwalu index focus logged its second straight sub-three-confirmation day, with the provisional 21-day zero-incidence countdown clock for the health zone now on its second day. Director Prof Jean-Jacques Muyembe-Tamfum confirms the fourteenth-cohort sequencing run posted cleanly to Virological.org under the post-EUL data-share protocol — phylogenetic placement still shows a single BDBV introduction with no second spillover — and the fifteenth cohort opens 06:00 CAT Thursday.

MSF Rwampara 3 June 22:30 CAT (4 June 02:00 CEST) Wednesday late-evening admissions wrap: 6 new lab-confirmed cases, 16 recoveries and 1 in-ETC death across the Wednesday window — recoveries outpaced admissions for a fifth consecutive day and combined Rwampara + Bunia-annexe occupancy eased to 27 of 58 beds. Site lead Dr Marie-José Frémery reports the thirteenth MEURI mAb114 cohort completed 14h post-infusion observation without adverse events and the cumulative confirmed-case fatality ratio inside the ETC network now sits below 19% for patients admitted within 48h of symptom onset and below 11% for those admitted within 24h; the joint MSF / DRC Red Cross safe-and-dignified-burial corridor handled 2 dignified burials.

Uganda Ministry of Health 3 June 22:30 EAT (4 June 02:00 CEST) Wednesday late-evening Kampala bulletin: the Uganda confirmed line moves from 34 to 35 after a single new BDBV confirmation in a known Mbarara cluster contact, with no new deaths across the Wednesday window — a third consecutive zero-death day. Health Minister Dr Jane Ruth Aceng confirms all 35 Uganda cases remain linked to identified clusters with no community-source transmission detected, and the Mulago and Mbarara MEURI mAb114 cohorts continue without adverse events; the Mpondwe–Kasindi, Bunagana and Kasese border-screening lines hold at continuous operation and the next briefing is queued for 09:00 EAT Thursday.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 3 June 03:00 CEST Wednesday post-midnight Geneva statement on BDBV: cumulative line list at 232 lab-confirmed cases (198 DRC + 34 Uganda) and 248 deaths against 1 400+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Tuesday-evening close, with the previous-24h confirmed-case and death deltas both the lowest since the outbreak was declared. Tedros reports the original Mongbwalu focus recorded its first zero-new-confirmation day on Tuesday and the Rwampara curve continues to fall, while residual transmission concentrates on the Bunia and Kampala–Mbarara axes; the IMST has opened a provisional 21-day zero-incidence countdown clock for the Mongbwalu health zone. WHO holds the PHEIC in force but confirms the DG-statement cadence steps down to twice-weekly (Wednesday and Saturday) from this readout as the response consolidates into sustained control; next DG statement queued for Saturday 6 June.

INRB Kinshasa's 2 June 22:00 CAT (3 June 02:00 CEST) Tuesday late-evening tally: 11 new BDBV PCR-positive confirmations across the Tuesday window (3 Mongbwalu + 4 Rwampara + 4 Bunia) and 3 new deaths within the confirmed cohort, taking the DRC confirmed line to 198. The three Mongbwalu confirmations are the lowest single-window count for the index focus since the outbreak was declared, with no new confirmation logged there in the back half of the window. Director Prof Jean-Jacques Muyembe-Tamfum confirms the thirteenth-cohort sequencing run posted cleanly to Virological.org under the post-EUL data-share protocol — phylogenetic placement still shows a single BDBV introduction with no second spillover — and the fourteenth cohort opens 06:00 CAT Wednesday.

MSF Rwampara 2 June 22:30 CAT (3 June 02:00 CEST) Tuesday late-evening admissions wrap: 8 new lab-confirmed cases, 18 recoveries and 2 in-ETC deaths across the Tuesday window — recoveries outpaced admissions for a fourth consecutive day and combined Rwampara + Bunia-annexe occupancy eased to 32 of 58 beds. Site lead Dr Marie-José Frémery reports the twelfth MEURI mAb114 cohort completed 14h post-infusion observation without adverse events and the cumulative confirmed-case fatality ratio inside the ETC network now sits below 20% for patients admitted within 48h of symptom onset and below 12% for those admitted within 24h; the joint MSF / DRC Red Cross safe-and-dignified-burial corridor handled 3 dignified burials.

Uganda Ministry of Health 2 June 22:30 EAT (3 June 02:00 CEST) Tuesday late-evening Kampala bulletin: the Uganda confirmed line moves from 33 to 34 after a single new BDBV confirmation in a known Mbarara cluster contact, with no new deaths across the Tuesday window — a second consecutive zero-death day. Health Minister Dr Jane Ruth Aceng confirms all 34 Uganda cases remain linked to identified clusters with no community-source transmission detected, and the Mulago and Mbarara MEURI mAb114 cohorts continue without adverse events; the Mpondwe–Kasindi, Bunagana and Kasese border-screening lines hold at continuous operation and the next briefing is queued for 09:00 EAT Wednesday.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 2 June 03:00 CEST Tuesday post-midnight Geneva statement on BDBV: cumulative line list at 220 lab-confirmed cases (187 DRC + 33 Uganda) and 243 deaths against 1 365+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Monday-evening close, with the daily death delta now at its lowest since the outbreak was declared. WHO holds the PHEIC in force but notes the response has moved from surge to sustained control; the IMST projects the Mongbwalu and Rwampara foci could reach a 21-day zero-incidence target by late June if the current trajectory holds. Next DG statement queued for Wednesday 3 June.

INRB Kinshasa's 1 June 22:00 CAT (2 June 02:00 CEST) Monday late-evening tally: 14 new BDBV PCR-positive confirmations across the Monday window (5 Mongbwalu + 5 Rwampara + 4 Bunia) and 3 new deaths within the confirmed cohort, taking the DRC confirmed line to 187. The higher confirmation count reflects the second Bunia annexe's sample throughput rather than rising incidence; Director Prof Jean-Jacques Muyembe-Tamfum confirms the twelfth-cohort sequencing run posted cleanly to Virological.org and the thirteenth cohort opens 06:00 CAT Tuesday.

MSF Rwampara 1 June 22:30 CAT (2 June 02:00 CEST) Monday late-evening admissions wrap: 10 new lab-confirmed cases, 16 recoveries and 2 in-ETC deaths across the Monday window, with combined Rwampara + Bunia-annexe occupancy at 38 of 58 beds. Site lead Dr Marie-José Frémery reports the eleventh MEURI mAb114 cohort completed observation without adverse events and the cumulative confirmed-case fatality ratio inside the ETC network has fallen below 20% for patients admitted within 48h of symptom onset; the safe-burial corridor handled 4 dignified burials.

Uganda Ministry of Health 1 June 22:30 EAT (2 June 02:00 CEST) Monday late-evening Kampala bulletin: the Uganda confirmed line moves from 31 to 33 after 2 new BDBV confirmations among known Mbarara and Kampala cluster contacts, with no new deaths across the Monday window — a first since the Uganda chain opened. All confirmed Uganda cases remain linked to identified clusters with no community-source transmission detected; the next briefing is queued for 09:00 EAT Tuesday.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 1 June 03:00 CEST Monday post-midnight Geneva statement on BDBV: cumulative line list at 194 lab-confirmed cases (163 DRC + 31 Uganda) and 238 deaths against 1 300+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Sunday-evening close, with the case-fatality ratio among confirmed-and-treated cases continuing to fall as MEURI mAb114 access scales across the Rwampara, Bunia, Mulago and Mbarara treatment centres. Tedros notes the epidemic curve in the original Mongbwalu and Rwampara foci is flattening while transmission persists along the Bunia and Kampala–Mbarara axes; next DG statement queued for Tuesday 2 June.

INRB Kinshasa's 31 May 22:00 CAT (1 June 02:00 CEST) Sunday late-evening tally: 12 new BDBV PCR-positive confirmations across the Sunday window (5 Mongbwalu + 4 Rwampara + 3 Bunia) and 4 new deaths within the confirmed cohort, taking the DRC confirmed line to 163. Director Prof Jean-Jacques Muyembe-Tamfum confirms the eleventh-cohort sequencing run published cleanly to Virological.org; phylogenetic placement continues to show a single BDBV introduction with no evidence of a second spillover, and the twelfth cohort opens 06:00 CAT Monday.

MSF Rwampara 31 May 22:30 CAT (1 June 02:00 CEST) Sunday late-evening admissions wrap: 9 new lab-confirmed cases, 15 recoveries and 2 in-ETC deaths across the Sunday window, with bed occupancy down to 36 of 46 as the recovery rate held above admissions for a second day. A second 12-bed MSF treatment annexe at Bunia opened to admissions Sunday to relieve the Rwampara catchment; the tenth MEURI mAb114 cohort completed observation without adverse events.

Uganda Ministry of Health 31 May 22:30 EAT (1 June 02:00 CEST) Sunday late-evening Kampala bulletin: the Uganda confirmed line moves from 29 to 31 after 2 new BDBV confirmations — a Mbarara contact and a Kasese border-screening pickup — with 1 in-ETC death. No new districts affected; the Mpondwe–Kasindi and Bunagana border-post screening lines hold at continuous operation and the next briefing is queued for 09:00 EAT Monday.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 31 May 02:00 CEST Sunday post-midnight Geneva statement on BDBV: cumulative line list now at 171 lab-confirmed cases (142 DRC + 29 Uganda) and 231 deaths against 1 230+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Saturday-evening close at 22:00 CAT, with the previous-24h death delta the smallest since the 17 May PHEIC as the first full cohorts complete the WHO Emergency Use Listing mAb114 MEURI protocol and present earlier. Tedros confirms the US$ 87M WHO Contingency Fund appeal closed fully subscribed overnight after the Saudi and EU top-ups landed; next DG statement queued for Monday 1 June 03:00 CEST.

INRB Kinshasa's 30 May 22:00 CAT (31 May 02:00 CEST) Saturday late-evening sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 13 new BDBV PCR-positive confirmations across the Saturday window (6 Mongbwalu HZ + 4 Rwampara HZ + 3 Bunia HZ) and 4 new deaths within the confirmed cohort — the lowest single-window confirmed-cohort fatality count since the PHEIC, consistent with earlier presentation and the scaling MEURI mAb114 deployment. The DRC confirmed line now stands at 142 across thirteen Ituri health zones plus Kinshasa, Goma and North Kivu; Director Prof Jean-Jacques Muyembe-Tamfum confirms the tenth-cohort run published cleanly to Virological.org under the post-EUL data-share protocol with the eleventh cohort opening 06:00 CAT Sunday.

MSF Rwampara 30 May 22:30 CAT (31 May 02:00 CEST) Saturday late-evening admissions wrap from site lead Dr Marie-José Frémery: the 46-bed Rwampara Ebola Treatment Centre admitted 14 patients across the Saturday window with 10 new lab-confirmed cases, 13 recoveries and 2 in-ETC deaths among confirmed cases — recoveries overtook admissions for the first time and bed occupancy eased to 41 of 46. The ninth MEURI mAb114 cohort of 11 patients completed 14h post-infusion observation without adverse events under the formal WHO Emergency Use Listing; the joint MSF / DRC Red Cross safe-and-dignified-burial corridor handled 6 burials across the window.

Uganda Ministry of Health 30 May 22:30 EAT (31 May 02:00 CEST) Saturday late-evening Kampala bulletin: the Uganda confirmed-case line moves from 26 to 29 across the Saturday window after the Central Emergency Surveillance and Response Support Laboratory (Wandegeya) confirms 3 new BDBV cases — two further Mbarara cluster contacts and a Kampala health worker — with 1 in-ETC death in the Mulago MEURI cohort. Health Minister Dr Jane Ruth Aceng confirms the first Mulago mAb114 cohort of 6 completed infusion without adverse events; the next briefing is queued for 09:00 EAT Sunday.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 30 May 02:00 CEST Saturday post-midnight Geneva statement on BDBV — wired after the Friday WHO Emergency Use Listing final-decision plenary close: cumulative line list now at 145 lab-confirmed cases (119 DRC + 26 Uganda) and 224 deaths against 1 168+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Friday-evening close at 22:00 CAT, with the previous-26h delta at +11 confirmations and +6 deaths concentrated in Mongbwalu, Rwampara, Bunia and the Kampala-Mbarara-Fort Portal axis. Tedros confirms the WHO EUL final-decision plenary at 14:00 CEST Friday cleanly issued the rolling-review Emergency Use Listing for the MEURI cross-species mAb114 protocol with a strong positive recommendation — the first EUL for a cross-species filovirus mAb application — and the US$ 87M WHO Contingency Fund appeal has now passed 94% subscription after the Friday Korean, Australian and Gates Foundation top-ups landed in the WHO escrow; next DG statement queued for 03:00 CEST Saturday.

WHO Emergency Use Listing Secretariat formally publishes the 29 May 14:00 CEST final-decision plenary outcome on the cross-species mAb114 MEURI protocol for Bundibugyo virus disease at 23:48 CEST Friday under the rolling-review post-decision cadence — the first EUL extension of a Zaire-ebolavirus-licensed monoclonal antibody to a cross-species filovirus indication. EUL Secretariat head Dr Rogerio Gaspar confirms the listing carries a positive provisional recommendation for compassionate-use and MEURI deployments across all WHO regions, with the post-decision conditions framework requiring 90-day rolling clinical follow-up returns from each deploying centre and a six-month post-listing review. The African Medicines Agency expedited-review track that fed the EUL is now closed; next EUL Secretariat note queued for the Tuesday 3 June 14:00 CEST post-listing 96-hour review.

INRB Kinshasa's 29 May 22:00 CAT (30 May 02:00 CEST) Friday late-evening sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 11 new BDBV PCR-positive confirmations across the Friday window (5 Mongbwalu HZ + 4 Rwampara HZ + 2 Bunia HZ) and 6 new deaths within the confirmed cohort, pushing the DRC confirmed-case line to 119 across thirteen Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the Friday ninth-cohort 28-sample sequencing run on the Bunia mobile-platform feed published cleanly to Virological.org at 20:08 CAT under the post-EUL data-share protocol, with the joint NICD / Palacios-lab phylogenetic-placement update following at 21:24 CAT; the tenth cohort run opens at 06:00 CAT Saturday and the next bulletin is queued for 12:00 CAT Saturday after the WHO AFRO regional briefing.

Africa CDC Addis Ababa IMST 30 May 03:00 CAT (02:00 CEST) Saturday post-midnight tile: the regional incident-management cell confirms the joint DRC + Uganda BDBV line at 145 confirmed / 224 deaths after Friday's +11 confirmations and +6 deaths, with the African Medicines Agency expedited-review track formally handed off to the WHO Emergency Use Listing post-decision conditions framework after the Friday 14:00 CEST EUL plenary cleanly issued the rolling-review listing for the cross-species mAb114 MEURI protocol. Director-General Dr Jean Kaseya confirms the Kayanza Burundi border-post screening line is now at 102-hour continuous operation without backlogs, the cross-border surveillance posture across DRC, Uganda, South Sudan, Rwanda and Burundi holds at full operational tempo, and the second Phase-2 tranche disbursement from the Africa Union ad-hoc Pandemic Fund convening is queued for the Monday morning WHO AFRO / UNICEF / Africa CDC tri-recipient transfer. Next IMST update queued for 06:00 CAT Saturday.

MSF Rwampara 29 May 22:30 CAT (30 May 02:00 CEST) Friday late-evening admissions wrap from site lead Dr Marie-José Frémery: the combined 46-bed Rwampara Ebola Treatment Centre is at 45 of 46 beds occupied on the Friday-evening count after 12 admissions, 8 new lab-confirmed cases and 11 recoveries across the Friday window with 2 in-ETC deaths among confirmed cases; the eighth MEURI mAb114 cohort of 11 patients completed the 14h post-infusion observation without adverse events and the ninth cohort of 11 patients opens at 06:00 CAT Saturday — the first cohort under the formal WHO EUL listing. The joint MSF / DRC Red Cross safe-burial corridor handled 8 dignified burials across the Friday window; the tenth mobile sequencing cohort opens 06:00 CAT Saturday with results back to INRB by 12:00 CAT.

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 30 May 02:00 CEST Saturday post-midnight clinical note on Dr Peter Stafford: the second alternate-day PCR sweep ran clean at 14:38 CEST Friday on the joint BNI / Charité panel with the cumulative viral-load decline now at −5.4 log10 from baseline and stable hepatic, renal and cardiac function. The patient completed an unsupervised 90-minute outdoor garden walk in the BNI isolation-ward courtyard under the post-cycle rehabilitation protocol and tolerated the introduction of a supervised resistance-band rehab circuit. The joint BNI / RKI / Charité treatment team holds the prognosis at 'favourable, on convalescent trajectory — discharge horizon mid-June' and confirms the next alternate-day PCR sweep is firm for Sunday 31 May morning; spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-12 post-arrival sweep.

Uganda Ministry of Health 29 May 22:30 EAT (30 May 02:00 CEST) Friday late-evening Kampala bulletin: the Uganda confirmed-case line moves from 24 to 26 across the Friday window after the Central Emergency Surveillance and Response Support Laboratory (Wandegeya) confirms 2 new BDBV cases — a third Mbarara Regional Referral Hospital HCW linked to the Tuesday-confirmed index cluster and a Kasese transit case picked up at the Mpondwe–Kasindi border-post screening line — and 1 in-ETC death in the Kampala MEURI cohort. Health Minister Dr Jane Ruth Aceng confirms the Mulago and Mbarara isolation wards have stood up the first post-EUL formal MEURI mAb114 deployments under the new WHO Emergency Use Listing, with the first Mulago cohort of 6 patients opening at 09:00 EAT Saturday; National Task Force convened at 18:30 EAT alongside Africa CDC IMST and the next briefing is queued for 09:00 EAT Saturday.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 28 May 02:00 CEST Thursday post-midnight Geneva statement on BDBV — wired after the Wednesday WHO EUL technical-committee preparatory close: cumulative line list now at 123 lab-confirmed cases (99 DRC + 24 Uganda) and 212 deaths against 1 042+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Wednesday-evening close at 22:00 CAT, with the previous-26h delta at +11 confirmations and +9 deaths across Mongbwalu, Rwampara, Bunia and the Kampala-Mbarara-Fort Portal axis. Tedros confirms the WHO Emergency Use Listing rolling-review file on the MEURI cross-species mAb114 is firm for the EUL final-decision plenary at Friday 29 May 14:00 CEST after the Wednesday technical-committee read-out closed clean with a positive provisional recommendation, and the US$ 87M WHO Contingency Fund appeal has reached 88% subscription with Norway, Ireland and the EU Commission Wednesday top-ups landing in the WHO escrow.

INRB Kinshasa's 27 May 22:00 CAT (28 May 02:00 CEST) Wednesday late-evening sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 9 new BDBV PCR-positive confirmations across the Wednesday window (4 Mongbwalu HZ + 3 Rwampara HZ + 2 Bunia HZ) and 8 new deaths within the confirmed cohort, pushing the DRC confirmed-case line to 99 across twelve Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the Wednesday seventh-cohort 26-sample sequencing run on the Bunia mobile-platform feed published cleanly to Virological.org at 20:05 CAT, with the joint NICD / Palacios-lab phylogenetic-placement update following at 21:18 CAT; the eighth cohort run opens at 06:00 CAT Thursday and the next bulletin is queued for 12:00 CAT Thursday after the WHO AFRO regional briefing.

Africa CDC Addis Ababa IMST 28 May 03:00 CAT (02:00 CEST) Thursday post-midnight tile: the regional incident-management cell confirms the joint DRC + Uganda BDBV line at 123 confirmed / 212 deaths after Wednesday's +11 confirmations and +9 deaths, with the WHO Emergency Use Listing rolling-review file on the African Medicines Agency MEURI cross-species mAb114 recommendation cleanly progressed past the Wednesday 14:00 CEST technical-committee read-out and now firmed for the Friday 29 May 14:00 CEST EUL final-decision plenary. Director-General Dr Jean Kaseya confirms the new Kayanza Burundi border-post screening line is now at 54-hour continuous operation without backlogs, the cross-border surveillance posture across DRC, Uganda, South Sudan, Rwanda and Burundi holds at full operational tempo, and the Phase-2 first-tranche disbursement from the Africa Union ad-hoc Pandemic Fund convening is queued for the Thursday morning WHO AFRO / UNICEF / Africa CDC tri-recipient transfer. Next IMST update queued for 06:00 CAT Thursday.

MSF Rwampara 27 May 22:30 CAT (28 May 02:00 CEST) Wednesday late-evening admissions wrap from site lead Dr Marie-José Frémery: the combined 46-bed Rwampara Ebola Treatment Centre is at 43 of 46 beds occupied on the Wednesday-evening count after 10 admissions, 7 new lab-confirmed cases and 14 recoveries across the Wednesday window with 3 in-ETC deaths among confirmed cases; the sixth MEURI mAb114 cohort of 10 patients completed the 14h post-infusion observation without adverse events and the seventh cohort of 11 patients is on for 06:00 CAT Thursday under the rolling protocol. The joint MSF / DRC Red Cross safe-burial corridor handled 9 dignified burials across the Wednesday window; the eighth mobile sequencing cohort opens 06:00 CAT Thursday with results back to INRB by 12:00 CAT.

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 28 May 02:00 CEST Thursday post-midnight clinical note on Dr Peter Stafford: the first alternate-day PCR sweep ran clean at 14:42 CEST Wednesday on the joint BNI / Charité panel with the cumulative viral-load decline now at −5.1 log10 from baseline and stable hepatic and renal function. The patient now tolerates a full diet, unsupervised 180-minute ambulation and the introduction of a supervised stair-climb circuit in the rehab annexe under the post-cycle rehabilitation protocol. The joint BNI / RKI / Charité treatment team holds the prognosis at 'favourable, on early-convalescent trajectory' and confirms the next alternate-day PCR sweep is firm for Friday 30 May morning; spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-10 post-arrival sweep.

CDC Acting Director Dr Demetre Daskalakis' 27 May 18:30 ET (28 May 02:00 CEST) Wednesday late-evening Atlanta telebriefing on BDBV: no U.S. cases linked to the DRC + Uganda outbreak, EOC remains at Activation Level 1 through the Wednesday handover, Title 42 entry restrictions on non-US travellers ex DRC, Uganda or South Sudan in the prior 21 days are active across all 18 airports of entry with 7 010 travellers screened over the past 204 hours, and the BARDA mAb114 IND for compassionate-use cross-species deployments now lists 21 active slots after the Lyon Émile-Muller hospital and the Rome Spallanzani isolation suite came online Wednesday. Daskalakis confirms the daily White House and HHS Secretary briefings hold the steady Tuesday cadence and reports the post-Memorial Day inbound passenger volume held within the modelled baseline through Wednesday; next Daskalakis telebriefing is queued for 17:00 ET Thursday.

WHO Regional Office for Africa (AFRO) Brazzaville 28 May 03:00 SAST (02:00 CEST) Thursday post-midnight regional sitrep: the joint DRC + Uganda BDBV response footprint now spans twelve Ituri health zones plus Kinshasa, Goma and North Kivu in DRC, and Kampala, Mbarara, Fort Portal, Kasese and Bundibugyo District in Uganda; cross-border surveillance escalations remain active at the Goma–Gisenyi, Bunia–Mahagi, Mpondwe–Kasindi, Cyanika Rwanda and Kayanza Burundi crossings under joint EAC and ICGLR coordination. Regional Director Dr Matshidiso Moeti confirms the WHO AFRO-led permanent rotating presence at Mongbwalu holds steady at 36 responders cycling through 14-day shifts after the Wednesday Pandemic Fund first-tranche disbursement firmed the fourth-slot Mongbwalu intake for Saturday 31 May, and the joint AFRO / Africa CDC Bunia field-coordination cell is locked in for the Friday EUL final-decision feed; next AFRO sitrep queued for 06:00 CAT Thursday.

Uganda Ministry of Health 27 May 22:30 EAT (28 May 02:00 CEST) Wednesday late-evening Kampala bulletin: the Uganda confirmed-case line moves from 22 to 24 across the Wednesday window after the Central Emergency Surveillance and Response Support Laboratory (Wandegeya) confirms 2 new BDBV cases — a second Fort Portal Regional Referral Hospital HCW linked to the Tuesday-confirmed index cluster and a Kasese transit-corridor case picked up at the Mpondwe–Kasindi border-post screening line — and 1 in-ETC death in the Kampala MEURI cohort. Health Minister Dr Jane Ruth Aceng confirms the IFRC-led Kayanza Burundi cross-border cooperation MOU operational annexes are now in full operational tempo across all five Uganda districts; National Task Force convened at 18:30 EAT alongside Africa CDC IMST and the next briefing is queued for 09:00 EAT Thursday.

ECDC Stockholm's 28 May 02:00 CEST Thursday post-midnight tile holds EU/EEA risk at VERY LOW for the general population and LOW for HCWs handling BDBV-linked specimens after the Wednesday-evening cluster grew to 123 confirmed / 212 deaths on the joint INRB / Uganda CPHL / WHO AFRO read, with the previous-26h delta adding 11 confirmations across Mongbwalu, Rwampara, Bunia and the Kampala-Mbarara-Fort Portal axis. Acting Director Andrea Ammon's post-midnight memo notes the BNI Hamburg primer-panel refresh now covers 17 EU/EEA reference labs after the Wednesday Greek (Athens) secondary-confirmation feed came online, and the joint HSC ebola item ran cleanly at the Wednesday 14:00 CEST technical-secretariat read-out under the Belgian co-chair with all 27 EU/EEA member states aligned on the joint primer-panel standing-order; next ECDC tile queued for 14:00 CEST Thursday.

Reuters Africa-desk wire at 02:00 CEST Thursday 28 May from Bunia synthesises the Wednesday-evening agency briefings around the BDBV response: joint DRC + Uganda line at 123 lab-confirmed cases and 212 deaths against 1 042+ suspected cases per the INRB / Uganda CPHL / WHO AFRO close at 22:00 CAT, BNI Hamburg Dr Stafford first alternate-day PCR sweep clean Wednesday with cumulative viral-load down −5.1 log10 and the patient now in supervised stair-climb rehab, WHO EUL final-decision plenary firm for Friday 29 May 14:00 CEST after the Wednesday technical-committee read-out closed clean, MSF Rwampara seventh MEURI cohort (n=11) on for 06:00 CAT Thursday, and the Uganda line moving to 24 after one Fort Portal HCW and one Kasese transit case. Africa-bureau chief David Lewis confirms the WHO Contingency Fund appeal is at 88% subscription.

UNICEF New York 27 May 20:00 ET (28 May 02:00 CEST) Wednesday late-evening response brief from Executive Director Catherine Russell: 728 metric tonnes of WASH and PPE supplies have now moved through the Goma airbridge into Ituri Province since the response opened, with 48 RCCE (risk communication and community engagement) teams operating across the twelve affected DRC health zones plus the five active Uganda districts. UNICEF confirms the first Phase-2 tranche of US$ 7.4M from the Africa Union ad-hoc Pandemic Fund convening was wired cleanly to the UNICEF DRC escrow at 16:48 EAT Wednesday for immediate disbursement against the community-engagement and child-protection workstreams; the cross-border child-protection corridor footprint across Mpondwe–Kasindi, Cyanika Rwanda and Kayanza Burundi remains at full operational tempo through the Thursday handover.

WHO Director-General Dr Tedros Adhanom Ghebreyesus issues a 27 May 02:00 CEST Wednesday post-midnight Geneva statement on BDBV — wired after the Tuesday WHO EUL technical-committee read-out close: cumulative line list now at 112 lab-confirmed cases (90 DRC + 22 Uganda) and 203 deaths against 998+ suspected cases per the joint INRB / Uganda CPHL / WHO AFRO Tuesday-evening close at 22:00 CAT, with the previous-26h delta at +11 confirmations and +9 deaths across Mongbwalu, Rwampara, Bunia and the Kampala-Mbarara axis. Tedros confirms the WHO Emergency Use Listing rolling-review file on the MEURI cross-species mAb114 cleared the Wednesday 14:00 CEST EUL technical-committee read-out with a positive provisional recommendation and now progresses to the EUL final-decision stage on Friday 29 May, and the US$ 87M WHO Contingency Fund appeal has reached 84% subscription with Denmark, Australia and the Netherlands Tuesday top-ups landing in the WHO escrow.

INRB Kinshasa's 26 May 22:00 CAT (27 May 02:00 CEST) Tuesday late-evening sequencing-and-confirmation tally: the joint INRB / Mongbwalu rapid-response panel posts 9 new BDBV PCR-positive confirmations across the Tuesday window (4 Mongbwalu HZ + 3 Rwampara HZ + 2 Bunia HZ) and 8 new deaths within the confirmed cohort, pushing the DRC confirmed-case line to 90 across twelve Ituri health zones plus Kinshasa, Goma and North Kivu. Director Prof Jean-Jacques Muyembe-Tamfum confirms the Tuesday sixth-cohort 24-sample sequencing run on the Bunia mobile-platform feed published cleanly to Virological.org at 19:50 CAT, with the joint NICD / Palacios-lab phylogenetic-placement update following at 21:10 CAT; the seventh cohort run opens at 06:00 CAT Wednesday and the next bulletin is queued for 12:00 CAT Wednesday after the WHO AFRO regional briefing.

Africa CDC Addis Ababa IMST 27 May 03:00 CAT (02:00 CEST) Wednesday post-midnight tile: the regional incident-management cell confirms the joint DRC + Uganda BDBV line at 112 confirmed / 203 deaths after Tuesday's +11 confirmations and +9 deaths, with the WHO Emergency Use Listing rolling-review file on the African Medicines Agency MEURI cross-species mAb114 recommendation cleanly progressed past the Wednesday 14:00 CEST technical-committee read-out and now bound for the Friday 29 May EUL final-decision stage. Director-General Dr Jean Kaseya reiterates the cross-border surveillance posture across DRC, Uganda, South Sudan, Rwanda and Burundi with the new Kayanza Burundi border-post screening line at 30-hour continuous operation; the Africa Union ad-hoc Pandemic Fund convening at 14:00 EAT Tuesday formally allocated the US$ 22M UNICEF Phase-2 earmark plus a parallel US$ 18M WHO AFRO operational tranche. Next IMST update queued for 06:00 CAT Wednesday.

MSF Rwampara 26 May 22:30 CAT (27 May 02:00 CEST) Tuesday late-evening admissions wrap from site lead Dr Marie-José Frémery: the combined 46-bed Rwampara Ebola Treatment Centre is at 44 of 46 beds occupied on the Tuesday-evening count after 11 admissions, 7 new lab-confirmed cases and 13 recoveries across the Tuesday window with 3 in-ETC deaths among confirmed cases; the fifth MEURI mAb114 cohort of 9 patients completed the 14h post-infusion observation without adverse events and the sixth cohort of 10 patients is on for 06:00 CAT Wednesday under the rolling protocol. The joint MSF / DRC Red Cross safe-burial corridor handled 8 dignified burials across the Tuesday window; the seventh mobile sequencing cohort opens 06:00 CAT Wednesday with results back to INRB by 12:00 CAT.

Bernhard-Nocht-Institut für Tropenmedizin (BNI) Hamburg 27 May 02:00 CEST Wednesday post-midnight clinical note on Dr Peter Stafford: the third mAb114 cycle completed cleanly at 14:18 CEST Tuesday in the high-security isolation ward without adverse infusion-reaction events, and the 12h post-third-cycle data on the joint BNI / Charité PCR panel shows the viral-load decline holding (cumulative −4.7 log10 from baseline) with stable hepatic and renal function. The patient now tolerates a full diet, unsupervised 150-minute ambulation and supervised resistance-band exercises in the courtyard. The joint BNI / RKI / Charité treatment team upgrades the prognosis to 'favourable, on early-convalescent trajectory' and confirms the patient now moves from daily to alternate-day PCR sweeps from Wednesday; spouse Dr Rebekah Stafford and colleague Dr Patrick LaRochelle remain asymptomatic and PCR-negative on the day-9 post-arrival sweep.